Efficacy of anti-influenza immunoglobulin (FLU-IGIV) in ferrets and mice infected with 2009 pandemic influenza virus
| Autor: | Hongyu Qiu, Russell Pronyk, E. Bart Tarbet, Shantha Kodihalli, Douglas Barker, Trevor Carnelley, Hanne Andersen, F. Salih Muhammad |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oseltamivir 030106 microbiology Dose-Response Relationship Immunologic Antibodies Viral Placebo Antiviral Agents Virus Seasonal influenza Mice 03 medical and health sciences chemistry.chemical_compound Influenza A Virus H1N1 Subtype Orthomyxoviridae Infections Pharmacokinetics Virology Animals Humans Medicine Pandemics Survival rate Pharmacology Mice Inbred BALB C biology business.industry Ferrets Immunoglobulins Intravenous virus diseases Viral Load respiratory tract diseases 030104 developmental biology chemistry biology.protein Female Antibody business Viral load |
| Zdroj: | Antiviral Research. 180:104753 |
| ISSN: | 0166-3542 |
| Popis: | Seasonal influenza causes significant morbidity and mortality around the world each year, even with the use of vaccines and antivirals. There is a need for more effective treatments for severe and hospitalized cases of influenza. In this study, we have tested the efficacy of a human plasma-derived IgG product (FLU-IGIV) against seasonal influenza in mouse and ferret models of influenza infection. FLU-IGIV successfully protected mice (100% survival) against lethal influenza infection. Also, the survival rate observed with FLU-IGIV treatment was better than the survival rate observed with oseltamivir (60% survival). FLU-IGIV significantly reduced the viral load in the lungs compared to placebo (PBS) in ferrets infected with influenza A/California/07/2009 (H1N1pdm09) virus. Overall, these studies demonstrate the efficacy of human plasma-derived FLU-IGIV in relevant animal models of influenza virus infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect