Stimuli-responsive prodrug of non-steroidal anti-inflammatory drug diclofenac: self-immolative drug release with turn-on near-infrared fluorescence

Autor:	Abu Sufian, Debojit Bhattacherjee, Pallavi Barman, Abhay Srivastava, Rajkumar P. Thummer, Krishna P. Bhabak
Rok vydání:	2022
Předmět:	Drug Liberation Diclofenac Anti-Inflammatory Agents Non-Steroidal Materials Chemistry Metals and Alloys Ceramics and Composites Prodrugs General Chemistry Reactive Oxygen Species Fluorescence Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials
Zdroj:	Chemical Communications. 58:7833-7836
ISSN:	1364-548X 1359-7345
DOI:	10.1039/d2cc02132c
Popis:	Reactive oxygen species (ROS)-responsive near infrared (NIR) fluorogenic prodrug DCI-ROS is developed for the self-immolative release of diclofenac (DCF) with turn-on fluorescence. The non-toxic prodrug exhibited turn-on red fluorescence with endogenous ROS in cancer cells and inhibited COX-2 expression in the inflammation-induced macrophage cells. The prodrug strategy thus would be helpful for the controlled fluorogenic delivery of DCF for inflammatory diseases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b5dfe6f7b94f92a266ed8a15d47161 https://doi.org/10.1039/d2cc02132c Zobrazit plný text záznamu