A Copper(II) Thiolate from Reductive Cleavage of an S-Nitrosothiol
| Autor: | Karsten Meyer, Timothy H. Warren, Marie M. Melzer, Kamille D. Williams, Susanne Mossin, Shiyu Zhang, Allan Jay P. Cardenas |
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| Rok vydání: | 2012 |
| Předmět: |
Protein function
S-Nitrosothiols Molecular Structure chemistry.chemical_element Crystallography X-Ray Nitric Oxide Photochemistry Copper Reversible reaction Nitric oxide Inorganic Chemistry chemistry.chemical_compound chemistry Coordination Complexes Reductive cleavage Polymer chemistry Sulfhydryl Compounds Transition metal thiolate complex Physical and Theoretical Chemistry Oxidation-Reduction |
| Zdroj: | Inorganic Chemistry. 51:8658-8660 |
| ISSN: | 1520-510X 0020-1669 |
| DOI: | 10.1021/ic301356h |
| Popis: | S-Nitrosothiols RSNO represent circulating reservoirs of nitric oxide activity in the plasma and play intricate roles in protein function control in health and disease. While nitric oxide has been shown to reductively nitrosylate copper(II) centers to form copper(I) complexes and ENO species (E = R(2)N, RO), well-characterized examples of the reverse reaction are rare. Employing the copper(I) β-diketiminate [Me(2)NN]Cu, we illustrate a clear example in which an RS-NO bond is cleaved to release NO(gas) with formation of a discrete copper(II) thiolate. The addition of Ph(3)CSNO to [Me(2)NN]Cu generates the three-coordinate copper(II) thiolate [Me(2)NN]CuSCPh(3), which is unstable toward free NO. |
| Databáze: | OpenAIRE |
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