Oncogenic roles of astrocyte elevated gene-1 (AEG-1) in osteosarcoma progression and prognosis
| Autor: | Shijun Sun, Shi-Cong Yang, Zunfu Ke, Shuhua Li, Xiao-Peng Mao, Wenfang Chen, Feng Wang, Liantang Wang |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
musculoskeletal diseases
Oncology Adult Male Cancer Research medicine.medical_specialty Cell Gene Expression Bone Neoplasms Kaplan-Meier Estimate Biology medicine.disease_cause Metastasis Young Adult Internal medicine Cell Line Tumor medicine Humans Neoplasm Invasiveness Cell Proliferation Pharmacology Gene knockdown Osteosarcoma Cell growth Cancer Membrane Proteins RNA-Binding Proteins medicine.disease Prognosis medicine.anatomical_structure Gene Knockdown Techniques Multivariate Analysis Molecular Medicine Biomarker (medicine) Matrix Metalloproteinase 2 Female RNA Interference Carcinogenesis Cell Adhesion Molecules |
| Zdroj: | Cancer biologytherapy. 12(6) |
| ISSN: | 1555-8576 |
| Popis: | Astrocyte elevated gene-1 (AEG-1) is overexpressed in several cancers and plays an important role in cancer progression. However, AEG-1 expression, biological function, and clinical significance in osteosarcoma have not been uncovered. Utilizing manipulated human osteosarcoma cell lines and osteosarcoma tissues, we found that increasing expression of AEG-1 enhanced osteosarcoma cell proliferation and invasion in vitro, and knockdown of AEG-1 significantly attenuated osteosarcoma cell malignancy. Moreover, AEG-1 was overexpressed in osteosarcoma tissues, and overexpression of AEG-1 was strongly associated with gender (p = 0.018), clinical stages (p < 0.001), classification (p < 0.001), metastasis (p = 0.013), differentiation (p < 0.001), and poor survival (p = 0.021). Mechanistic studies conducted in vitro and in vivo revealed that AEG-1-mediated carcinogenesis and invasiveness might be through upregulating MMP-2. Taken together, our data strongly suggest that AEG-1 plays a crucial role in osteosarcoma progression through MMP-2, and AEG-1 could be a useful biomarker for the prediction of osteosarcoma progression and prognosis. |
| Databáze: | OpenAIRE |
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