The disordered boundary of the cell: emerging properties of membrane-bound intrinsically disordered proteins
| Autor: | Irrem-Laareb Mohammad, Borja Mateos, Miquel Pons |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
QH301-705.5
sgnalling environment membrane proteins 02 engineering and technology Intrinsically disordered proteins General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Cellular and Molecular Neuroscience Phase (matter) z-compartmentalization Molecule Animals Humans Biology (General) Lipid bilayer liquid phase separation bio nano composites 030304 developmental biology 0303 health sciences Chemistry Cell Membrane dBc src family kinases General Medicine 021001 nanoscience & nanotechnology Electrostatics crowding Membrane src-Family Kinases Membrane protein Chemical physics cell boundaries intrinsically disordered proteins 0210 nano-technology |
| Zdroj: | Biomolecular Concepts, Vol 10, Iss 1, Pp 25-36 (2019) |
| ISSN: | 1868-5021 |
| Popis: | We define the disordered boundary of the cell (DBC) as the system formed by membrane tethered intrinsically disordered protein regions, dynamically coupled to the underlying membrane.The emerging properties of the DBC makes it a global system of study, which cannot be understood from the individual properties of their components. Similarly, the properties of lipid bilayers cannot be understood from just the sum of the properties of individual lipid molecules.The highly anisotropic confined environment, restricting the position and orientation of interacting sites, is affecting the properties of individual disordered proteins. In fact, the collective effect caused by high concentrations of disordered proteins extend beyond the sum of individual effects.Examples of emerging properties of the DBC include enhanced protein-protein interactions, protein-driven phase separations, Z-compartmentalization, and protein modulated electrostatics. |
| Databáze: | OpenAIRE |
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