Mechanical ventilation results in progressive contractile dysfunction in the diaphragm
| Autor: | Scott K. Powers, Jeff S. Coombes, R. Andrew Shanely, Michael J. Cicale, Thomas J. Koesterer, Stephen L. Dodd, Darin Van Gammeren, Michael J. McKenzie |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Artificial ventilation
Physiology medicine.medical_treatment Diaphragm Diaphragmatic breathing Blood Pressure Isometric exercise In Vitro Techniques Body Temperature Rats Sprague-Dawley Physiology (medical) Isometric Contraction Respiratory muscle Medicine Animals Homeostasis Respiratory system Mechanical ventilation Specific force business.industry Body Weight Hydrogen-Ion Concentration Respiration Artificial Diaphragm (structural system) Rats Disease Models Animal Anesthesia Disease Progression Female Blood Gas Analysis business Respiratory Insufficiency Muscle Contraction |
| Zdroj: | Journal of applied physiology (Bethesda, Md. : 1985). 92(5) |
| ISSN: | 8750-7587 |
| Popis: | These experiments tested the hypothesis that a relatively short duration of controlled mechanical ventilation (MV) will impair diaphragmatic maximal specific force generation (specific Po) and that this force deficit will be exacerbated with increased time on the ventilator. To test this postulate, adult Sprague-Dawley rats were randomly divided into one of six experimental groups: 1) control ( n = 12); 2) 12 h of MV ( n = 4); 3) 18 h of MV ( n = 4); 4) 18 h of anesthesia and spontaneous breathing ( n = 4); 5) 24 h of MV ( n = 7); and 6) 24 h of anesthesia and spontaneous breathing ( n = 4). MV animals were anesthetized, tracheostomized, and ventilated with room air. Animals in the control group were acutely anesthetized but were not exposed to MV. Animals in two spontaneous breathing groups were anesthetized and breathed spontaneously for either 18 or 24 h. No differences ( P > 0.05) existed in diaphragmatic specific Pobetween control and the two spontaneous breathing groups. In contrast, compared with control, all durations of MV resulted in a reduction ( P < 0.05) in diaphragmatic specific tension at stimulation frequencies ranging from 15 to 160 Hz. Furthermore, the MV-induced decrease in diaphragmatic specific Powas time dependent, with specific Pobeing ∼18 and ∼46% lower ( P < 0.05) in animals mechanically ventilated for 12 and 24 h, respectively. These data support the hypothesis that relatively short-term MV impairs diaphragmatic contractile function and that the magnitude of MV-induced force deficit increases with time on the ventilator. |
| Databáze: | OpenAIRE |
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