Serum levels of psoriasin (S100A7) and koebnerisin (S100A15) as potential markers of atherosclerosis in patients with psoriasis

Autor:	E. Abu El-Hamed, Sara M. Awad, Dalia Abdel Aziz Attallah, Ayman M. Mahran, Ragaa H. M. Salama
Rok vydání:	2018
Předmět:	Adult Male S100A7 medicine.medical_specialty Dermatology Carotid Intima-Media Thickness Gastroenterology S100 Calcium Binding Protein A7 Proinflammatory cytokine 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Psoriasis Area and Severity Index Internal medicine Psoriasis medicine Humans In patient business.industry S100 Proteins Case-control study Middle Aged Atherosclerosis medicine.disease Case-Control Studies 030220 oncology & carcinogenesis Subclinical atherosclerosis Female S100A15 business Biomarkers
Zdroj:	Clinical and Experimental Dermatology. 43:262-267
ISSN:	0307-6938
DOI:	10.1111/ced.13370
Popis:	Psoriasin (S100A7) and koebnerisin (S100A15) are proinflammatory proteins upregulated in psoriasis, but their relation to atherosclerosis remains unclear.To evaluate the role of serum psoriasin and koebnerisin as possible markers for subclinical atherosclerosis in patients with psoriasis.Serum levels of psoriasin and koebnerisin were measured by ELISA in 45 patients with psoriasis and in 45 healthy controls (HCs). Intima-media thickness (IMT) of the right and left common carotid arteries was measured to detect the presence of subclinical atherosclerosis. Clinical severity of psoriasis was estimated using the Psoriasis Area and Severity Index (PASI).Compared with HCs, patients with psoriasis had significantly higher levels of psoriasin (26.61 ± 22.45 ng/mL vs. 6.31 ± 1.68 ng/mL, P 0.001) and koebnerisin (21.2 ± 13.12 ng/mL vs. 12.2 ± 4.67 ng/mL, P = 0.001), and significantly higher IMT values (1.07 ± 0.4 mm vs. 0.61 ± 0.1 mm, P 0.001). A positive correlation was observed between IMT and PASI (r = 0.78, P 0.001), serum psoriasin (r = 0.48, P 0.01) and serum koebnerisin (r = 0.48, P 0.01). Patients with psoriasis with subclinical atherosclerosis had higher serum levels of koebnerisin compared with patients without subclinical atherosclerosis (P = 0.04), which was not observed for psoriasin (P = 0.94).Serum psoriasin and koebnerisin correlate with IMT, underlining their value as a potential link between psoriasis and atherosclerosis. In particular, koebnerisin seems to be a useful marker of subclinical atherosclerosis in patients with psoriasis.
Databáze:	OpenAIRE
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