The Role of Autophagy in the Maintenance of Stemness and Differentiation of Mesenchymal Stem Cells
| Autor: | Marta Columbaro, Margherita Cortini, Francesca Perut, Sofia Avnet, Francesca Vittoria Sbrana, Angelo De Milito, Nicola Baldini |
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| Přispěvatelé: | Sbrana, Francesca Vittoria, Cortini, Margherita, Avnet, Sofia, Perut, Francesca, Columbaro, Marta, De Milito, Angelo, Baldini, Nicola |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Senescence Pluripotent Stem Cells Cancer Research Cellular homeostasis Biology Regenerative medicine Models Biological 03 medical and health sciences Autophagy Animals Homeostasis Humans Progenitor cell Hypoxia Mesenchymal stem cell Cell Proliferation Stemne Acidity Cell Differentiation Mesenchymal Stem Cells Cell Biology Hydrogen-Ion Concentration Cell biology 030104 developmental biology Differentiation Stem cell Intracellular |
| Zdroj: | Stem cell reviews and reports. 12(6) |
| ISSN: | 2629-3277 |
| Popis: | Regulated self-consumption, also known as autophagy, is an evolutionary conserved process that degrades cellular components by directing them to the lysosomal compartment of eukaryotic cells. As a major intracellular degradation and recycling pathway, autophagy is crucial for maintaining and remodeling cellular homeostasis during normal cellular and tissue development. Recent studies have demonstrated that autophagy is necessary for the maintenance of cellular stemness and for a number of differentiation processes, including the lineage determination of mesenchymal stem cells. These are multipotent progenitor cells with self-renewal capacities that can give rise to a subset of tissues and thus hold a consistent potential in regenerative medicine. Here, we review the current literature on the complex liaison between autophagy induced by various extra- or intracellular stimuli and the molecular targets that affect mesenchymal stem cells proliferation and differentiation. |
| Databáze: | OpenAIRE |
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