Inhibitory Effects of Phenylpropanoid Derivatives from Oenanthe javanica on Antigen-Stimulated Degranulation in RBL-2H3 Cells
| Autor: | Emi Takahashi, Ruka Iwahana, Yoshinobu Ishikawa, Toshihiro Murata, Tatsuo Katagiri, Yuko Sakamoto, Mizuki Abe, Kenroh Sasaki |
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| Rok vydání: | 2019 |
| Předmět: |
food.ingredient
Stereochemistry Pharmaceutical Science 01 natural sciences Lignans Analytical Chemistry HeLa Lactones chemistry.chemical_compound food Drug Discovery Oenanthe javanica Animals Humans Dicarboxylic Acids Mast Cells Cytotoxicity Pharmacology Lignan Phenylpropionates Phenylpropanoid biology 010405 organic chemistry Chemistry Organic Chemistry Degranulation Absolute configuration Sugar Acids biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Oenanthe Molecular Medicine Acid hydrolysis HeLa Cells |
| Zdroj: | Journal of Natural Products. 82:1518-1526 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | Two diacyldaucic acids (1 and 2), an α,β-unsaturated γ-lactone-type lignan (3) and its derivatives (4-6), and 12 known compounds were isolated from a traditional East Asian vegetable, Oenanthe javanica. The absolute configuration of 1 was validated by obtaining (+)-osbeckic acid through acid hydrolysis. The absolute configurations of 3-5 were determined by comparing their experimental and computed ECD data. The conclusion was supported by applying the phenylglycine methyl ester method to 3. Compound 6 was obtained as an interconverting mixture of isomers in a 3:1 trans- cis ratio. Several water-soluble components (1, 3, and 6) showed concentration-dependent inhibitory effects on antigen-stimulated degranulation in RBL-2H3 cells without producing any direct cytotoxicity against RBL-2H3 or HeLa cells. |
| Databáze: | OpenAIRE |
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