Plasma Peptide Concentrations and Peptide-Reactive Immunoglobulins in Patients with Eating Disorders at Inclusion in the French EDILS Cohort (Eating Disorders Inventory and Longitudinal Survey)
| Autor: | Sébastien Grigioni, J. Delay, Guillaume Colange, André Petit, Gregory Lambert, Romain Legrand, Camille Deroissart, Nicolas Lucas, Najate Achamrah, Saïda Azhar, A. Rimbert, M.-P. Tavolacci, André Gillibert, Pierre Déchelotte, Marie-Anne Le Solliec, L. Belmonte, Tiphaine Saillard, Julie Rondeaux, Adèle Lamarre, Muriel Quillard, M. Galmiche, Moïse Coëffier, V. Folope |
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| Přispěvatelé: | Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), TargEDys Rouen, Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de nutrition [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de biostatistiques [CHU Rouen] |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Leptin
Male medicine.medical_treatment immunoglobulins Peptide Immunoglobulin G Body Mass Index Cohort Studies 0302 clinical medicine Glucagon-Like Peptide 1 Insulin Longitudinal Studies 10. No inequality ComputingMilieux_MISCELLANEOUS 2. Zero hunger chemistry.chemical_classification Nutrition and Dietetics biology digestive oral and skin physiology 3. Good health eating disorder Ghrelin Female France Antibody lcsh:Nutrition. Foods and food supply hormones hormone substitutes and hormone antagonists medicine.medical_specialty 030209 endocrinology & metabolism lcsh:TX341-641 Enzyme-Linked Immunosorbent Assay Article Feeding and Eating Disorders 03 medical and health sciences Internal medicine medicine Humans Peptide YY human plasma business.industry Endocrinology chemistry biology.protein peptides business [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition 030217 neurology & neurosurgery Food Science Hormone |
| Zdroj: | Nutrients Volume 12 Issue 2 Nutrients, MDPI, 2020, 12 (2), pp.522. ⟨10.3390/nu12020522⟩ Nutrients, Vol 12, Iss 2, p 522 (2020) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12020522 |
| Popis: | Eating disorders (EDs) are increasingly frequent. Their pathophysiology involves disturbance of peptide signaling and the microbiota&ndash gut&ndash brain axis. This study analyzed peptides and corresponding immunoglobulin (Ig) concentrations in groups of ED. In 120 patients with restrictive (R), bulimic (B), and compulsive (C) ED, the plasma concentrations of leptin, glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and insulin were analyzed by Milliplex and those of acyl ghrelin (AG), des-acyl ghrelin (DAG), and &alpha melanocyte-stimulating hormone (&alpha MSH) by ELISA kits. Immunoglobulin G (in response to an antigen) concentrations were analyzed by ELISA, and their affinity for the respective peptide was measured by surface plasmon resonance. The concentrations of leptin, insulin, GLP-1, and PYY were higher in C patients than in R patients. On the contrary, &alpha MSH, DAG, and AG concentrations were higher in R than in C patients. After adjustment for body mass index (BMI), differences among peptide concentrations were no longer different. No difference in the concentrations of the IgG was found, but the IgG concentrations were correlated with each other. Although differences of peptide concentrations exist among ED subtypes, they may be due to differences in BMI. Changes in the concentration and/or affinity of several anti-peptide IgG may contribute to the physiopathology of ED or may be related to fat mass. |
| Databáze: | OpenAIRE |
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