Aeroallergen sensitization influences quality of life and comorbidities in patients with nasal polyposis
| Autor: | Carlos Colás, Magdalena Lluch-Bernal, Ana M. Navarro, Javier Montoro, Antonio Valero, María Cesárea Sánchez, E Antón, Ignacio Dávila, Víctor Matheu, Carmen Rondon, María Teresa Dordal, María Dolores Ibáñez, B Fernández-Parra |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Allergy Visual analogue scale Comorbidity Nasal congestion Atopy Nasal Polyps Quality of life Internal medicine Air Pollution Surveys and Questionnaires Immunology and Allergy Medicine Humans Asthma Rhinitis rhinorrhea business.industry Incidence General Medicine Articles Allergens Middle Aged medicine.disease Cross-Sectional Studies Otorhinolaryngology Spain Physical therapy Disease Progression Quality of Life Asthma Aspirin-Induced Female Immunization medicine.symptom business |
| Popis: | Background Nasal polyposis (NP) is a chronic inflammatory disease of unknown etiology that impairs quality of life (QoL). The role of atopy in NP is not established. The aim of this study was to describe the clinical characteristics and QoL in a broad sample of patients with NP and to evaluate the influence of allergy on this disease. Methods A multicenter, observational, cross-sectional study was conducted in 67 allergy units in Spain. NP and nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity were diagnosed following EP3OS guidelines. Rhinitis and asthma were classified following Allergic Rhinitis and Its Impact on Asthma and the Global Initiative for Asthma guidelines, respectively. Skin tests with a battery of aeroallergens were performed on all patients. A visual analog scale (VAS) and Short-Form 12 (SF-12) and 31-item Rhinosinusitis Outcome Measure (RSOM 31) questionnaires were completed by all the patients. Results Of the 671 patients included, 611 were evaluable. Mean age was 46 years and 50% of patients were men. Also, 50% were atopic. Asthma was present in 66% of patients and NSAID hypersensitivity was present in 26%. The most frequent symptoms were nasal congestion and rhinorrhea. Mean value of VAS was 58.6. Global health and bodily pain were the items most frequently identified in the SF-12 questionnaire and nasal and ocular symptoms in the RSOM-31 questionnaire. There was a good correlation between VAS score and QoL (p < 0.0001). Rhinitis was more severe in nonallergic patients. Asthma was more frequent in atopic patients, whereas ASA triad was more frequent in nonatopic patients. Atopic patients showed higher VAS scores and worse QoL. Conclusion Atopic NP patients showed worse QoL, higher incidence of asthma and a less severe form of rhinitis than non-atopic patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|