Effects of Bariatric Surgeries on the Size of Myocardial Infarction and Ghrelin Level in Rats with Experimental Decompensated Type 2 Diabetes Mellitus
| Autor: | G. V. Semikova, Evgeniia Pochkaeva, A. E. Neimark, K. V. Dergach, Dmitry Sonin, Irina Zelinskaya, A. O. Schpakov, O. M. Berko, N. M. Todosenko, A. Yu. Babenko, Ya. G. Toropova, O. V. Kornyushin, Michael M. Galagudza, Larisa Litvinova |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Sleeve gastrectomy medicine.medical_specialty Necrosis medicine.medical_treatment Myocardial Infarction Bariatric Surgery Diet High-Fat Gastroenterology Streptozocin General Biochemistry Genetics and Molecular Biology Diabetes Mellitus Experimental 03 medical and health sciences 0302 clinical medicine Gastrectomy Diabetes mellitus Internal medicine medicine Animals Myocardial infarction Rats Wistar business.industry Type 2 Diabetes Mellitus General Medicine medicine.disease Streptozotocin Ghrelin Rats Disease Models Animal Glucose 030104 developmental biology Diabetes Mellitus Type 2 medicine.symptom business 030217 neurology & neurosurgery Ghrelin level medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 168:210-213 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-019-04676-w |
| Popis: | The effects of bariatric surgeries (sleeve gastrectomy and ileal transposition) on the dynamics of changes in ghrelin level were studied in rats with severe decompensated type 2 diabetes mellitus under conditions of glucose challenge as well as on the size of myocardial infarction in these animals. Diabetes was modelled by high fat diet and a single administration of streptozotocin (25 mg/kg, intraperitoneally). Both bariatric surgeries significantly decreased glucose-induced ghrelin level in the blood of rats with type 2 diabetes mellitus, which attested to an increase in the tissue sensitivity to ghrelin. Sleeve gastrectomy resulted in a decrease in the size of myocardial infarction in diabetic rats, which was calculated as the ratio of the necrosis zone to the zone of the risk of myocardial infarction. Ileal transposition had no effect on this parameter. Our data can be used as the basis for optimization of treatment approaches when using bariatric surgery in the treatment of patients with severe forms of type 2 diabetes mellitus with a high risk of cardiovascular diseases. |
| Databáze: | OpenAIRE |
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