Left Ventricular Hypertrophy, Subclinical Atherosclerosis, and Inflammation
| Autor: | James A. de Lemos, Sameer K. Mehta, Sabina A. Murphy, Ronald M Peshock, J. Eduardo Rame, Russell M. Canham, Amit Khera, Mark H. Drazner |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Heart disease Population Blood Pressure Coronary Artery Disease Left ventricular hypertrophy Asymptomatic Muscle hypertrophy Cohort Studies Coronary artery disease Risk Factors Internal medicine Internal Medicine medicine Humans cardiovascular diseases Myocardial infarction education Inflammation education.field_of_study Univariate analysis business.industry Middle Aged medicine.disease Coronary Vessels Magnetic Resonance Imaging Texas C-Reactive Protein Cross-Sectional Studies Endocrinology Multivariate Analysis Cardiology Calcium Female Hypertrophy Left Ventricular medicine.symptom Tomography X-Ray Computed business |
| Zdroj: | Hypertension. 49:1385-1391 |
| ISSN: | 1524-4563 0194-911X |
| Popis: | To elucidate mechanisms by which left ventricular (LV) hypertrophy (LVH) increases the risk of atherosclerotic heart disease, we sought to determine whether LVH is independently associated with coronary artery calcium (CAC) and serum C-reactive protein (CRP) levels in the general population. The Dallas Heart Study is a population-based sample in which 2633 individuals underwent cardiac MRI to measure LV structure, electron beam CT to measure CAC, and measurement of plasma CRP. We used univariate and multivariable analyses to determine whether LV mass and markers of concentric LV hypertrophy or dilation were associated with CAC and CRP. Increasing quartiles of LV mass indexed to fat-free mass, LV wall thickness, and concentricity, but not LV volume, were associated with CAC in both men and women ( P P P =0.001 for both) in gender-stratified univariate analyses, although these associations did not persist in multivariable analysis. In conclusion, concentric LVH is an independent risk factor for subclinical atherosclerosis. LVH is also associated with an inflammatory state as reflected in elevated CRP levels, although this relationship appears to be mediated by comorbid conditions. These data likely explain in part why individuals with LVH are at increased risk for myocardial infarction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|