Are interleukin-1 gene polymorphisms risk factors or disease modifiers in AD?
| Autor: | Judith Harris, Helen Lemmon, Marie-Christine Chartier-Harlin, Jean-Charles Lambert, Takeshi Iwatsubo, C. Lendon, Elaine K. Green, D M Mann, D. St Clair |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Genotype medicine.medical_treatment Disease Cohort Studies Degenerative disease Gene Frequency Alzheimer Disease Risk Factors Polymorphism (computer science) medicine Humans Age of Onset Risk factor Aged Aged 80 and over Analysis of Variance Chi-Square Distribution Polymorphism Genetic business.industry Interleukin Middle Aged medicine.disease Cytokine Immunology Female Neurology (clinical) Alzheimer's disease business Interleukin-1 Cohort study |
| Zdroj: | ResearcherID |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.58.10.1566 |
| Popis: | Polymorphisms in the interleukin-1 genes, IL-1A and IL-1B, have been associated with AD, but not in all studies. The authors genotyped the IL-1A(-889) and IL-1B(-511) polymorphisms in large independent cohorts of 503 control individuals and 395 patients with AD, and a further 100 with brain Abeta load. No evidence was found of risk for AD with these variants, nor of an effect on age at onset. However, an impact of IL-1B(-511) on Abeta(40) load (p < 0.05) was detected. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|