Reversal of quetiapine-induced altered mental status with physostigmine: a case series
| Autor: | Heather Ellsworth, Jon B. Cole, Carson R. Harris, Samuel J. Stellpflug |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Drug Dibenzothiazepines Physostigmine medicine.medical_specialty medicine.medical_treatment media_common.quotation_subject Less invasive Quetiapine Fumarate Young Adult Patient disposition Altered Mental Status Humans Medicine Intubation Glasgow Coma Scale media_common business.industry General Medicine Anesthesia Toxicity Emergency medicine Emergency Medicine Consciousness Disorders Quetiapine Female Cholinesterase Inhibitors Drug Overdose Emergency Service Hospital business Antipsychotic Agents medicine.drug |
| Zdroj: | The American Journal of Emergency Medicine. 30:950-953 |
| ISSN: | 0735-6757 |
| DOI: | 10.1016/j.ajem.2011.05.015 |
| Popis: | Quetiapine overdose is a clinical entity commonly encountered in emergency departments. Quetiapine is a drug with many mechanisms, including antimuscarinic effects. Traditionally, treatment of quetiapine toxicity has been primarily supportive care. Case reports exist documenting improvement in mental status in these patients after administration of physostigmine, a carbamate capable of reversing antimuscarinic toxicity. In this descriptive case series, 3 patients with quetiapine toxicity treated with physostigmine are reported. In each case, the patient had significant altered mental status that was rapidly reversed with administration of physostigmine. In all 3 cases, patient disposition was changed to a lower level of care, requiring less invasive monitoring. In 1 case, intubation was prevented. Because quetiapine toxicity is commonly encountered and the use of physostigmine in this setting is a potentially practice-altering treatment, emergency physicians should be aware of this phenomenon. |
| Databáze: | OpenAIRE |
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