Prevention of cancer through immunization: Prospects and challenges for the 21st century
| Autor: | John T. Schiller, Ian H. Frazer, D R Lowy |
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| Rok vydání: | 2007 |
| Předmět: |
Hepatitis B virus
Cervical cancer biology business.industry Hepatitis C virus Immunology Cancer Viral Vaccines Disease Helicobacter pylori medicine.disease_cause biology.organism_classification medicine.disease Cancer Vaccines Virology Immunization Neoplasms Bacterial Vaccines medicine Animals Humans Immunology and Allergy Infection control business |
| Zdroj: | European Journal of Immunology. 37:S148-S155 |
| ISSN: | 1521-4141 0014-2980 |
| DOI: | 10.1002/eji.200737820 |
| Popis: | Persistent infection by several microbial agents is responsible for at least 15% of cancer globally, including most cancers of the liver, stomach, and cervix. The recent development of vaccines that can prevent infection and premalignant disease caused by human papillomaviruses (HPV), which cause virtually all cases of cervical cancer as well as some other cancers, has focused renewed attention on infection control as a means of reducing the global cancer burden. For vaccines to prevent cancer-causing infection with hepatitis C virus, Helicobacter pylori, or Epstein Barr virus, new vaccine technologies to induce more effective protective responses are required. For the two available cancer control vaccines, designed to prevent infection with HPV and hepatitis B virus, the major challenge is to promote effective vaccine deployment through education programs and increased affordability/accessibility for underserved populations, particularly in the developing world, where the cancer burden attributable to infection by these two viruses is greatest. |
| Databáze: | OpenAIRE |
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