Evaluation of correlations between genetic variants and high-resolution computed tomography patterns in idiopathic pulmonary fibrosis
| Autor: | Michele Simbolo, Francesco Salton, Elisa Baratella, Fabiola Giudici, Saverio Tollot, Marco Confalonieri, Barbara Wade, Paola Confalonieri, Barbara Ruaro, Aldo Scarpa, Cristina Marrocchio, Mario Santagiuliana, Maria Assunta Cova |
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| Přispěvatelé: | Baratella, Elisa, Ruaro, Barbara, Giudici, Fabiola, Wade, Barbara, Santagiuliana, Mario, Salton, Francesco, Confalonieri, Paola, Simbolo, Michele, Scarpa, Aldo, Tollot, Saverio, Marrocchio, Cristina, Cova, MARIA ASSUNTA, Confalonieri, Marco |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
High-resolution computed tomography Medicine (General) interstitial lung disease idiopathic pulmonary fibrosis high‐resolution computed tomography (HRCT) familial idiopathic pulmonary fibrosis Familial idiopathic pulmonary fibrosis Clinical Biochemistry High-resolution computed tomog-raphy (HRCT) Idiopathic pulmonary fibrosis Interstitial lung disease high-resolution computed tomography (HRCT) Article 03 medical and health sciences 0302 clinical medicine R5-920 Usual interstitial pneumonia Internal medicine medicine 030212 general & internal medicine Medical diagnosis Clinical treatment medicine.diagnostic_test idiopathic pulmonary fibrosi business.industry Significant difference Genetic variants respiratory system medicine.disease humanities respiratory tract diseases 030228 respiratory system business |
| Zdroj: | Diagnostics, Vol 11, Iss 762, p 762 (2021) Diagnostics Volume 11 Issue 5 |
| Popis: | Background. Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease (ILD). This prospective observational study aimed at the evaluation of any correlation between genetic variants associated with IPF susceptibility and high-resolution computed tomography (HRCT) patterns. It also aimed at evidencing any differences in the HRTC pattern between the familial and sporadic form at diagnosis and after two years. Methods. A total of 65 IPF patients (mean age at diagnosis 65 ± 10) were enrolled after having given written informed consent. HRCT and genetic evaluations were performed. Results. A total of 19 familial (mean age 62 ± 15) and 46 sporadic (mean age 70 ± 9) IPF patients were enrolled. A statistically significant difference was evidenced in the HRTC pattern at diagnosis between the two groups. Sporadic IPF patients had a predominantly usual interstitial pneumonia (UIP) pattern compared with those patients with familial IPF (60.0% vs. 21.1%, respectively). Moreover, familial IPF patients had more alternative diagnoses than those with sporadic IPF (31.6% vs. 2.2%, respectively). Furthermore, there was a slight increase in the typical UIP pattern in the familial IPF group at two years from diagnosis. Conclusions. Genetic factors play a pivotal role in the risk of developing IPF. However, further studies are required to clarify how these genetic factors may guide clinical treatment decisions. |
| Databáze: | OpenAIRE |
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