THE EFFECT OF LOW IODINE DIET ON THYROID FUNCTION IN THE RAT*†
| Autor: | J. E. Rall, William L. Money, Rulon W. Rawson |
|---|---|
| Rok vydání: | 1952 |
| Předmět: |
endocrine system
Wolff–Chaikoff effect medicine.medical_specialty Goiter endocrine system diseases Endocrinology Diabetes and Metabolism Clinical Biochemistry Thyroid Gland chemistry.chemical_element Iodine in biology Thyroid Function Tests Iodine Biochemistry Thyroid function tests Endocrinology Internal medicine medicine Animals medicine.diagnostic_test Biochemistry (medical) Thyroid medicine.disease Diet Rats Viscera medicine.anatomical_structure chemistry Dietary Iodine Thyroid function |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 12:1495-1505 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-12-11-1495 |
| Popis: | IT HAS long been known that normal thyroid function is dependent upon an adequate intake of dietary iodine. In more recent years many studies have been made in an attempt to elucidate the exact role iodine plays in the development and function of the thyroid gland. The vast amount of data obtained on this subject has been amply discussed in many textbooks and review articles and will not be considered in detail in this report. In rats, as in most other vertebrates, thyroid changes develop when the dietary level of iodine is low. A deficiency in iodine intake produces a decrease in the synthesis of thyroid hormone and results in the formation of an hyperplastic goiter. The administration of iodine under such circumstances corrects this deficiency, and the gland assumes a more normal structure. In 1933 Levine, Remington and Von Kolnitz (1, 2) developed a low iodine diet which produced goiter in rats within five weeks. By the use of this diet and with replacement of iodine with potassium iodide, they conclud... |
| Databáze: | OpenAIRE |
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