Sporadic colorectal cancer â role of the commensal microbiota
| Autor: | Georgina L. Hold, Renate Kain, Emad M. El-Omar, Mairi Hope |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Inflammation
Colorectal cancer Cancer Biology Mouse model of colorectal and intestinal cancer medicine.disease Malignancy Microbiology Ulcerative colitis Disease Models Animal Lactobacillus Inactivation Metabolic Immunology Carcinogens Genetics medicine Animals Carbohydrate Metabolism Humans Adenocarcinoma Microbiome Colorectal Neoplasms Reactive Oxygen Species Molecular Biology Carcinogen |
| Zdroj: | FEMS Microbiology Letters. 244:1-7 |
| ISSN: | 1574-6968 0378-1097 |
| Popis: | There are vast numbers of bacteria present within the human colon that are essential for the host's well being in terms of nutrition and mucosal immunity. While certain members of the colonic microbiota have been shown to promote the host's health there are also numerous studies that have implicated other members of the colonic microbiota in the development of colorectal cancer, a prominent malignancy within the western world. In this review we consider the evidence for the role of bacteria in colorectal cancer from molecular and animal model studies. We focus on some of the mechanisms by which the colonic microbiota drives the progression towards colorectal malignancy including generation of reactive metabolites and carcinogens, alterations in host carbohydrate expression and induction of chronic mucosal inflammation. |
| Databáze: | OpenAIRE |
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