Lithium Use during Pregnancy and the Risk of Miscarriage

Autor:	Marco P. Boks, René S. Kahn, Veerle Bergink, Annabel Vreeker, Roel A. Ophoff, Eline M. P. Poels, Janneke Gilden, Astrid M. Kamperman
Přispěvatelé:	Psychiatry, Child and Adolescent Psychiatry / Psychology
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	medicine.medical_specialty Bipolar I disorder Lithium (medication) Clinical Sciences miscarriage lcsh:Medicine Reproductive health and childbirth Article Miscarriage 03 medical and health sciences 0302 clinical medicine medicine 030212 general & internal medicine Bipolar disorder LITHIUM USE perinatal lithium pregnancy bipolar disorder spontaneous abortion teratogenicity Pregnancy business.industry Obstetrics Contraception/Reproduction lcsh:R General Medicine Odds ratio medicine.disease 030227 psychiatry Multilevel logistic regression business medicine.drug
Zdroj:	Journal of Clinical Medicine Journal of Clinical Medicine; Volume 9; Issue 6; Pages: 1819 Journal of clinical medicine, vol 9, iss 6 Journal of Clinical Medicine, Vol 9, Iss 1819, p 1819 (2020) Journal of Clinical Medicine, 9(6):1819. Multidisciplinary Digital Publishing Institute (MDPI)
ISSN:	2077-0383
Popis:	Recent studies have provided new data on the teratogenicity of lithium. Less is known about the risk of miscarriage after lithium use during pregnancy. The aim of this study was to investigate the association between lithium use during pregnancy and miscarriage. Participants were women with bipolar I disorder and one or more pregnancies, of which information on medication use and pregnancy outcome was available (n = 443). The unadjusted odds ratios for miscarriage after lithium use during pregnancy was calculated. Multilevel logistic regression was used to calculate the odds ratio, adjusted for the age at conception and the clustering of pregnancies per woman. Miscarriages occurred in 20.8% of the lithium-exposed pregnancies (16/77), compared with 10.9% of the unexposed pregnancies (40/366) (OR = 2.14; 95% CI: 1.13–4.06). The adjusted odds ratio of miscarriage after lithium use during pregnancy was 2.94 (95% CI: 1.39–6.22). Lithium use during pregnancy may increase the risk of miscarriage.
Databáze:	OpenAIRE
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