Comparative study of the blood pressure effects of four different vegetable fats on young, spontaneously hypertensive rats
| Autor: | Heine H, Taube C, Werner Förster, J. Beitz, Block Hu, E. Naumann, Singer P, P. Hoffmann, P. Wortha |
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| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty food.ingredient Clinical chemistry Linoleic acid Blood Pressure Biology Biochemistry chemistry.chemical_compound Structure-Activity Relationship food Linseed oil Palm kernel Internal medicine Rats Inbred SHR medicine Animals Plant Oils Evening Primrose Oil Phospholipids chemistry.chemical_classification Organic Chemistry Body Weight Fatty Acids Cell Biology Organ Size Rats Endocrinology chemistry Fatty Acids Unsaturated Sunflower seed Polyunsaturated fatty acid Lipidology |
| Zdroj: | Lipids. 21(12) |
| ISSN: | 0024-4201 |
| Popis: | Following the suckling period, four groups of male four-week-old spontaneously hypertensive rats (SHR) were fed semisynthetic diets with 14% (by weight) of either sunflower seed oil [46% 18:2(n-6); linoleic acid (LA)-rich], linseed oil [62.5% 18:3(n-3) + 12.9% 18:2(n-6); alpha-linolenic acid (LNA)-rich], evening primrose oil [9.2% 18:3(n-6) + 71% 18:2(n-6); gamma-linolenic acid (LNA)-rich] or hydrogenated palm kernel fat [1.5% 18:2(n-6); polyunsaturated fatty acid (PUFA)-deficient], respectively, up to an age of 18 wk. All diets enriched with PUFA provoked an attenuation of hypertension development. The effect was lowest in the LA-rich group and highest in the gamma-LNA-rich group. Differences in fatty acid composition of renal phospholipids between groups reflect the fatty acids present in the respective dietary fats. Renomedullary production of PGF2 alpha was significantly reduced in alpha-LNA-rich and slightly diminished in gamma-LNA-rich fed rats. Aortic formation of 6-keto-PGF1 alpha and TXB2 was increased in animals fed the gamma-LNA-rich diet. Thus, the attenuation of hypertension development cannot be explained only by changes in prostanoid formation. Other mechanisms possibly involved should be pursued. |
| Databáze: | OpenAIRE |
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