Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma
| Autor: | Mohammed M. Alshehri, Divya Jain, Javad Sharifi-Rad, Sevgi Durna Daştan, Pracheta Janmeda, Krishn Kumar Agrawal, Rajib Hossain, Muhammad Torequl Islam, Yasaman Taheri, Rana Azeem Ashraf, Aliya Kipchakbayeva, Yogesh Murti, Mohammad Nabil Hossain, William C. Cho, Wasi Ullah Khan, Balakyz Yeskaliyeva |
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| Přispěvatelé: | Fen Fakültesi |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
MAPK/ERK pathway
Aging Carcinoma Hepatocellular Antineoplastic Agents Review Article medicine.disease_cause Fibroblast growth factor Biochemistry In vivo medicine Animals Humans PI3K/AKT/mTOR pathway Biological Products QH573-671 Kinase business.industry Liver Neoplasms Cell Biology General Medicine medicine.disease Hepatocellular carcinoma Cancer research Signal transduction Reactive Oxygen Species business Cytology Oxidative stress |
| Zdroj: | Oxidative Medicine and Cellular Longevity, Vol 2021 (2021) Oxidative Medicine and Cellular Longevity |
| ISSN: | 1942-0994 |
| Popis: | Hepatocellular carcinoma (HCC) is due to poor prognosis and lack of availability of effective treatment. Novel therapeutic strategies will be the fine tuning of intracellular ROS signaling to effectively deprive cells of ROS-induced tumor-promoting events. This review discusses the generation of ROS, the major signaling their modulation in therapeutics. We explore some of the major pathways involved in HCC, which include the VEGF, MAPK/ERK, mTOR, FGF, and Ser/Thr kinase pathways. In this review, we study cornerstone on natural bioactive compounds with their effect on hepatocarcinomas. Furthermore, we focus on oxidative stress and FDA-approved signaling pathway inhibitors, along with chemotherapy and radiotherapy enhancers which with early evidence of success. While more in vivo testing is required to confirm the findings presented here, our findings will aid future nonclinical, preclinical, and clinical studies with these compounds, as well as inspire medicinal chemistry scientists to conduct appropriate research on this promising natural compound and their derivatives. |
| Databáze: | OpenAIRE |
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