No association of toll-like receptor 2 polymorphisms with Alzheimer's disease in Han Chinese
| Autor: | Jin-Tai Yu, Wei-Zhen Cui, Yan-Ping Sun, Jiang-Rong Ou, Wei Zhang, Lan Tan |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Aging
Population Chromosome Disorders Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Asian People Alzheimer Disease Genotype Genetic predisposition medicine Humans Genetic Predisposition to Disease Allele education Gene Genetic Association Studies Genetics education.field_of_study General Neuroscience Haplotype medicine.disease Toll-Like Receptor 2 Neurology (clinical) Chromosome Deletion Chromosomes Human Pair 4 Geriatrics and Gerontology Alzheimer's disease Developmental Biology |
| Zdroj: | Neurobiology of Aging. 32:1924.e1-1924.e3 |
| ISSN: | 0197-4580 |
| Popis: | Toll-like receptor 2 (TLR2) represents a reasonable functional and positional candidate gene for Alzheimer's disease (AD) as it is located under the linkage region of AD on chromosome 4q, and is functionally involved in the microglia-mediated inflammatory response and amyloid β (Aβ) clearance. In the current study, 7 single nucleotide polymorphisms (SNPs) that span the TLR2 were selected and their associations with late-onset AD (LOAD) risk were assessed in a case-control sample comprising 785 individuals in a Han Chinese population. No significant differences in the frequency of TLR2 alleles, genotypes, and haplotypes in the AD cases were detected compared with the controls. TLR2 gene might not play a major role in the genetic predisposition to late-onset Alzheimer's disease in this population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect