Effects of prolonged exposure to interferon-alpha on the viability, proliferation, differentiation, and tumorigenicity of HL-60 promyelocytic leukemia cells
| Autor: | Makoto Takeuchi, Shunsaku Ando, Sumako Sueishi, Yasuiti Nagano |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Time Factors Igg fc receptors Proliferation differentiation Cell Survival Period (gene) Immunology Biology Esterase Leukemia Promyelocytic Acute Interferon Virology Internal medicine Interferon α Cricetinae medicine Tumor Cells Cultured Animals Humans Mesocricetus Cell Differentiation medicine.disease Molecular biology Prolonged exposure Leukemia Endocrinology Interferon Type I Cell Division Neoplasm Transplantation medicine.drug |
| Zdroj: | Journal of interferon research. 10(4) |
| ISSN: | 0197-8357 |
| Popis: | HL-60 promyelocytic leukemia cells were cultured continuously in the presence of 22,000 IU/ml of purified interferon-alpha (IFN-alpha) for up to 469 days. Study of the properties of the cells at various times during this period showed some changes in their expression of IgG Fc receptors, and in the maturation of the cells as indicated by their esterase content. The differences from control cells cultured in parallel were most marked after exposure to IFN-alpha for some 40-300 days, but were no longer seen after 400-470 days. The difference in tumorigenicity was significant after 150 days, but no longer after 300 days. |
| Databáze: | OpenAIRE |
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