Ethnic differences in infectious burden and the association with metabolic risk factors for cardiovascular disease: a cross-sectional analysis
| Autor: | Lara Hartog, Martijn S. van Rooijen, Joanne K Ujcic-Voortman, Irene G. M. van Valkengoed, Maria Prins |
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| Přispěvatelé: | APH - Global Health, APH - Methodology, Graduate School, AII - Infectious diseases, Infectious diseases, AII - Amsterdam institute for Infection and Immunity, APH - Health Behaviors & Chronic Diseases, Public and occupational health, ACS - Diabetes & metabolism |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Turkey Cross-sectional study Hypercholesterolemia Type 2 diabetes Disease 030204 cardiovascular system & hematology Logistic regression Infections Communicable Diseases Young Adult 03 medical and health sciences 0302 clinical medicine Infectious burden Risk Factors Diabetes mellitus Epidemiology Ethnicity Humans Medicine 030212 general & internal medicine Aged Netherlands business.industry lcsh:Public aspects of medicine Diabetes Public Health Environmental and Occupational Health lcsh:RA1-1270 Health Status Disparities Odds ratio Middle Aged medicine.disease Health Surveys Morocco Cross-Sectional Studies Diabetes Mellitus Type 2 Cardiovascular Diseases Hypertension Female business Body mass index Research Article Demography |
| Zdroj: | BMC Public Health, Vol 18, Iss 1, Pp 1-9 (2018) BMC public health, 18(1). BioMed Central BMC Public Health |
| ISSN: | 1471-2458 |
| DOI: | 10.1186/s12889-018-5162-x |
| Popis: | Background The burden of metabolic risk factors for cardiovascular disease (CVD), such as type 2 diabetes, elevated cholesterol and hypertension, is unequally distributed across ethnic groups. Recent findings suggest an association of infectious burden (IB) and metabolic risk factors, but data from ethnic groups are scarce. Therefore, we investigated ethnic differences in IB and its association with metabolic risk factors. Methods We included 440 Dutch, 320 Turkish and 272 Moroccan participants, 18–70 years, of the 2004 general health survey in Amsterdam, the Netherlands. IB was defined by seropositivity to the sum of 6 infections: Herpes Simplex Virus 1 and 2; Hepatitis A, B and C; and Helicobacter pylori. Associations between IB categories 4–6 (high), 3 (intermediate) and 0–2 (low) infections and metabolic risk factors were assessed by logistic regression. Finally, we determined the contribution of IB to the association between ethnicity and the metabolic risk factors by comparing adjusted logistic regression models with and without IB categories. Results A high IB was more frequently observed among the Turkish and Moroccans than among the Dutch. After adjustment for age, sex, ethnicity, educational level, physical activity and body mass index, high IB was associated with type 2 diabetes (odds ratio high vs low IB (OR) =2.14, 95%-confidence interval (CI) 1.05–4.36). The association was weaker and not statistically significant, for elevated cholesterol (OR = 1.39, 95%-CI 0.82–2.34) and hypertension (OR = 1.49, 95%-CI 0.88–2.51). IB attenuated ethnic differences particularly for type 2 diabetes. Conclusions Our study showed that Turkish and Moroccan adults in Amsterdam have a higher IB than Dutch adults, which was associated with the differences in type 2 diabetes. Due to the cross-sectional nature of the study, we cannot draw a conclusions with regards to the time-sequence of cause and effect. Nevertheless, the findings ask for further research into the nature of association of IB with metabolic risk factors in a longitudinal setting. |
| Databáze: | OpenAIRE |
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