Detection of multiple cytokines in the urine of patients with focal necrotising glomerulonephritis may predict short and long term outcome of renal function
| Autor: | Aikaterini Papagianni, Lazaros Gionanlis, Dimitrios Memmos, Helen Liakou, Christos Bantis, Afroditi Pantzaki, Kostas Pliakos, Maria Stangou, Panagiotis Giamalis, Georgios Efstratiadis |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Time Factors Urinary system Biopsy Immunology Renal function Kidney Kidney Function Tests Biochemistry Gastroenterology chemistry.chemical_compound Glomerulonephritis Epidermal growth factor Internal medicine Immunology and Allergy Medicine Humans Molecular Biology Macrophage inflammatory protein Aged Aged 80 and over medicine.diagnostic_test business.industry Hematology Middle Aged Immunohistochemistry Vascular endothelial growth factor Treatment Outcome chemistry Case-Control Studies Cytokines Female Renal biopsy business Transforming growth factor |
| Zdroj: | Cytokine. 57(1) |
| ISSN: | 1096-0023 |
| Popis: | Detection of urinary cytokines in pauci-immune focal segmental necrotizing glomerulonephritis (FSNGN) may provide valuable information about disease pathogenesis and prognosis.Epidermal growth factor (EGF), transforming growth factor (TGF-β1) and vascular endothelial growth factor (VEGF) were measured by ELISA, and Interleukins, monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein (MIP1β) by a multiplex cytokine assay, in 38 patients with FSNGN. Their levels were correlated with severity of histological findings and renal function outcome in short and long term.The percentage of crescents in renal biopsy had positive correlation with TGF-β1 (p=0.004) and IL-15 urinary excretion (p=0.01), and negative correlation with EGF (p=0.01). Increased urinary excretion of IL-6, IL-15, VEGF and MIP-1β was associated with poor renal function outcome, but increased levels of EGF, IL-2 and IL-9 predicted a favourable prognosis. In multiple regression analysis IL-6 and VEGF urinary levels were independent predictors of no-response at the acute phase (p=0.001 and p0.0001, respectively), while, IL-6 was the only factor (p=0.03) predicted worse outcome at the end of follow-up (39.4±45 months).Increased urinary excretion of IL-6, IL-15, VEGF, TGF-β1, MCP-1 and MIP-1β and reduced EGF, IL-2, IL-9 may be associated with histological damage and influence response to treatment in pauci-immune FSNGN. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect