Development of a new delivery system consisting in ‘drug–in cyclodextrin–in PLGA nanoparticles’
| Autor: | Marco Bragagni, António J. Almeida, Francesca Maestrelli, Matteo Cecchi, Paola Mura |
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| Rok vydání: | 2010 |
| Předmět: |
inorganic chemicals
Drug Materials science media_common.quotation_subject Pharmaceutical Science Nanoparticle Bioengineering Inclusion compound chemistry.chemical_compound Colloid and Surface Chemistry Polylactic Acid-Polyglycolic Acid Copolymer Oxaprozin mental disorders Copolymer medicine Organic chemistry Lactic Acid Particle Size Physical and Theoretical Chemistry Microparticle health care economics and organizations media_common chemistry.chemical_classification Cyclodextrins Drug Carriers Cyclodextrin Anti-Inflammatory Agents Non-Steroidal Organic Chemistry technology industry and agriculture respiratory system PLGA chemistry Nanoparticles Propionates Polyglycolic Acid Nuclear chemistry medicine.drug |
| Zdroj: | Journal of Microencapsulation. 27:479-486 |
| ISSN: | 1464-5246 0265-2048 |
| DOI: | 10.3109/02652040903515508 |
| Popis: | A combined approach based on drug cyclodextrin (CD) complexation and loading into PLGA nanoparticles (NP) has been developed to improve oxaprozin therapeutic efficiency. This strategy exploits the solubilizing and stabilizing properties of CDs and the prolonged-release and targeting properties of PLGA NPs. Drug-loaded NPs, prepared by double-emulsion, were examined for dimensions, zeta-potential and entrapment efficiency. Solid-state studies demonstrated the absence of drug-polymer interactions and assessed the amorphous state of the drug-CD complex loaded into NPs. Drug release rate from NPs was strongly influenced by the presence and kind of CD used. The percentage released at 24 h varied from 16% (plain drug-loaded NPs) to 50% (drug-betaCD-loaded NPs) up to 100% (drug-methylbetaCD-loaded NPs). This result suggests the possibility of using CD complexation not only to promote, but also to regulate drug release rate from NPs, by selecting the proper type of CD or CD combination. |
| Databáze: | OpenAIRE |
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