Reliability of visual assessment by non-expert nuclear medicine physicians and appropriateness of indications of [123I]FP-CIT SPECT imaging by neurologists in patients with early drug-naive Parkinson’s disease
| Autor: | Marleen A. Slim, Jan Booij, Sven R. Suwijn, Rob M.A. de Bie, Constant V. M. Verschuur |
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| Přispěvatelé: | Amsterdam Neuroscience - Neurodegeneration, Graduate School, Radiology and Nuclear Medicine, Neurology, APH - Aging & Later Life |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
0301 basic medicine Levodopa Parkinson's disease lcsh:R895-920 Concordance DAT SPECT 03 medical and health sciences 0302 clinical medicine Spect imaging parasitic diseases Visual assessment mental disorders Medicine Radiology Nuclear Medicine and imaging Cardiac imaging business.industry Parkinsonism Reliability medicine.disease nervous system diseases Indication Drug-naïve 030104 developmental biology business Nuclear medicine 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | EJNMMI research, 9(1):63. Springer Berlin EJNMMI Research, Vol 9, Iss 1, Pp 1-5 (2019) |
| ISSN: | 2191-219X |
| Popis: | Purpose To determine the reliability of visual assessment of [123I]FP-CIT SPECT imaging by non-experts in dopamine transporter (DAT) SPECT imaging in patients with early drug-naive Parkinson’s disease (PD). Also, we explored the indications of DAT SPECT imaging in clinical practice by neurologists. Methods We collected [123I]FP-CIT SPECT scans of the Levodopa in EArly Parkinson’s disease (LEAP) trial participants that were made prior to recruitment, as part of routine clinical work-up. All scans were reassessed by an expert in DAT imaging. A survey on the use of DAT SPECT imaging was sent to all referring neurologists. Results The concordance of the initial local assessment and the expert reassessment was 98.7%. The survey showed that neurologists requested DAT SPECT imaging in only 73.6% of patients to differentiate between a neurodegenerative disease and non-neurodegenerative parkinsonism. Conclusions Visual assessment of [123I]FP-CIT SPECT imaging by community nuclear medicine physicians in patients with early PD is reliable. Neurologists who request DAT SPECT scans are not always aware that the high accuracy is limited only to the differentiation between neurodegenerative and non-neurodegenerative parkinsonism. A significant portion of neurologists who request DAT SPECT scans is not always aware that the high accuracy is limited to the differentiation between neurodegenerative and non-neurodegenerative parkinsonism as DAT SPECT cannot reliably distinguish the various Parkinsonian syndromes. |
| Databáze: | OpenAIRE |
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