Serotoninergic Mechanisms of Immunomodulation Under Different Psychoemotional States: I. A role of 5-HT1aReceptor Subtype
| Autor: | E. L. Al'perina, Svetlana Davydova, L. V. Devoino, M. A. Cheido, G. V. Idova |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Agonist Serotonin medicine.medical_specialty medicine.drug_class medicine.medical_treatment Emotions Serotonin 5-HT1 Receptor Antagonists Serotonergic Mice Immunity Internal medicine Immune Tolerance polycyclic compounds medicine Animals heterocyclic compounds Rats Wistar Social Behavior Receptor Behavior Animal Mood Disorders business.industry musculoskeletal neural and ocular physiology General Neuroscience Brain Immunosuppression General Medicine Serotonin 5-HT1 Receptor Agonists Rats Serotonin Receptor Agonists Blockade Aggression Mice Inbred C57BL Endocrinology nervous system Receptor Serotonin 5-HT1A Mice Inbred CBA 5-HT1A receptor Serotonin Antagonists business Stress Psychological |
| Zdroj: | International Journal of Neuroscience. 118:1594-1608 |
| ISSN: | 1543-5245 0020-7454 |
| DOI: | 10.1080/00207450701768887 |
| Popis: | The present study demonstrates the involvement of serotonin (5-HT) receptors of the 5-HT 1A type in immunoinhibitory effect of 5-HTergic system of the brain. A selective agonist of 5-HT 1A receptors 8-OH-DPAT (1 mg/kg) induces the immunosuppression, whereas 5-HT 1A blockade with WAY-100635 (1 mg/kg) resulted in immunostimulation. It is also shown that immunomodulating effects of the drugs were dependent on psychoemotional status of animals acquired aggressive or submissive behavior under social conflict conditions. Activation of 5-HT 1A receptors produced a decrease of the immunity in aggressive mice, whereas 5-HT 1A receptor blockade caused immunostimulation in submissive animals. |
| Databáze: | OpenAIRE |
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