An extra virgin olive oil rich diet intervention ameliorates the nonalcoholic steatohepatitis induced by a high-fat 'Western-type' diet in mice

Autor: Franz Martín, Genoveva Berná, Bernat Soria, Enrique Jurado-Ruiz, Gladys M. Cahuana, Rocío Gallego-Durán, Enrique Martínez-Force, Manuel Romero Gómez, Lourdes M. Varela, Amparo Luque, Baukje de Roos
Přispěvatelé: Ministerio de Economía y Competitividad (España), European Commission, Junta de Andalucía
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
medicine.medical_specialty
CD36
Adipose tissue
Biology
Diet
High-Fat
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Non-alcoholic Fatty Liver Disease
Internal medicine
Nonalcoholic fatty liver disease
medicine
Animals
Adiponutrin
education
Olive Oil
Inflammation
education.field_of_study
Body Weight
Fatty liver
nutritional and metabolic diseases
food and beverages
Lipid metabolism
Organ Size
Lipid Metabolism
medicine.disease
Liver regeneration
Mice
Inbred C57BL
Oleic acid
030104 developmental biology
Endocrinology
High-fat diet
Adipose Tissue
Gene Expression Regulation
Liver
chemistry
Diet
Western
Phospholipases A2
Calcium-Independent
biology.protein
Cytokines
030211 gastroenterology & hepatology
lipids (amino acids
peptides
and proteins)
Extra virgin olive oil (EVOO)
Triolein
Food Science
Biotechnology
Zdroj: Digital.CSIC. Repositorio Institucional del CSIC
instname
Popis: [Scope]: We evaluated the protective effect of extra virgin olive oil (EVOO) in high-fat diets (HFDs) on the inflammatory response and liver damage in a nonalcoholic fatty liver disease (NAFLD) mouse model. [Methods and results]: C57BL/6J mice were fed a standard diet or a lard-based HFD (HFD-L) for 12 wk to develop NAFLD. HFD-fed mice were then divided into four groups and fed for 24 wk with the following: HFD-L, HFD-EVOO, HFD based on phenolics-rich EVOO, and reversion (standard diet). HFD-L-induced metabolic disorders were alleviated by replacement of lard with EVOO. EVOO diets improved plasma lipid profile and reduced body weight, plasma and epididymal fat INF-γ, IL-6 and leptin levels, and macrophage infiltration. Moreover, NAFLD activity scores were reduced. The liver lipid composition showed an increase in MUFAs, especially oleic acid, and a decrease in saturated fatty acids. Hepatic adiponutrin and Cd36 gene expression was upregulated in the EVOO groups. Liver ingenuity pathway analysis revealed in EVOO groups regulation of proteins involved in lipid metabolism, small molecule biochemistry, gastrointestinal disease, and liver regeneration. [Conclusion]: Dietary EVOO could repair HFD-induced hepatic damage, possibly via an anti-inflammatory effect in adipose tissue and modifications in the liver lipid composition and signaling pathways.
This study was supported by grants AGL2014-54585-R (Ministerio de Economía y Competitividad) and PAI-BIO311 (Junta de Andalucía). LMV is funded by Fondo Europeo de Desarrollo Regional (FEDER).
Databáze: OpenAIRE
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