Dual Directing-Groups-Assisted Redox-Neutral Annulation and Ring Opening of N-Aryloxyacetamides with 1-Alkynylcyclobutanols via Rhodium(III)-Catalyzed C–H/C–C Activations
| Autor: | Zhenliang Sun, Jin-Long Pan, Tuan-Qing Liu, Chao Chen, Man Wang, Chang Liu, Shu-Yu Zhang |
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| Rok vydání: | 2019 |
| Předmět: |
Annulation
010405 organic chemistry Organic Chemistry chemistry.chemical_element Regioselectivity 010402 general chemistry Ring (chemistry) 01 natural sciences Biochemistry Medicinal chemistry Redox 0104 chemical sciences Rhodium Catalysis chemistry.chemical_compound chemistry Functional group Physical and Theoretical Chemistry Benzofuran |
| Zdroj: | Organic Letters. 21:2823-2827 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.9b00812 |
| Popis: | A cascade [3 + 2] annulation and ring opening of N-aryloxyacetamides with 1-alkynylcyclobutanols via Rh(III)-catalyzed redox-neutral C-H/C-C activations using internal oxidative O-NHAc and -OH as the dual directing groups has been achieved. This reaction provided an efficient and regioselective approach to benzofuran derivatives with good functional group compatibility and high yields. |
| Databáze: | OpenAIRE |
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