Polymorphisms of Interleukin-1beta and beta3-Adrenergic Receptor in Japanese Patients With Nonalcoholic Steatohepatitis
| Autor: | Masafumi Ono, Makoto Hiroi, Toshiji Saibara, Shinji Iwasaki, Yoshihiro Hayashi, Hideaki Enzan, Saburo Onishi, Yasuko Nozaki, Naoaki Akisawa, Yoshihisa Nemoto |
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| Rok vydání: | 2004 |
| Předmět: |
Beta-3 adrenergic receptor
medicine.medical_specialty Medicine (miscellaneous) Toxicology digestive system Statistics Nonparametric Hepatitis Insulin resistance Asian People Gene Frequency Internal medicine Genotype Odds Ratio Genetic predisposition medicine Hyperinsulinemia Humans Allele frequency Aged Chi-Square Distribution Polymorphism Genetic business.industry Hypertriglyceridemia nutritional and metabolic diseases Middle Aged medicine.disease digestive system diseases Genotype frequency Fatty Liver Psychiatry and Mental health Endocrinology Receptors Adrenergic beta-3 business Interleukin-1 |
| Zdroj: | Alcoholism: Clinical and Experimental Research. 28:106S-110S |
| ISSN: | 1530-0277 0145-6008 |
| DOI: | 10.1111/j.1530-0277.2004.tb03226.x |
| Popis: | Background: Obesity, hypertriglyceridemia, and diabetes have been reported as frequent complications observed in patients with nonalcoholic steatohepatitis (NASH) in Western countries. The aim of this study was to investigate the genetic predisposition on NASH pathogenesis in the Japanese population. Methods: Genotypes of two previously described functional polymorphisms—β3-adrenergic receptor 190 T/A polymorphism, which results in Trp64Arg (W64R) amino acid replacement, and interleukin-1β-511 T/C polymorphism in the promoter sequence—were determined in 63 Japanese NASH patients and 100 healthy volunteers using polymerase chain reaction and restriction fragment length polymorphism. Results: β3-adrenergic receptor R allele frequency and the R/− (W/R and R/R) genotype frequency were significantly higher in NASH patients than those in control subjects. Interleukin-1β-511 T allele frequency and the T/T genotype frequency were significantly higher in NASH patients than those in control subjects. Obesity, hypertriglyceridemia, and hyperinsulinemia were associated with NASH patients with the R/− genotype, whereas an increase in fasting plasma glucose level and a decrease in insulinogenic index were associated with NASH patients with the W/W genotype. Conclusion: This study confirmed the contribution of obesity, glucose intolerance, and hypertriglyceridemia to NASH development in the Japanese population. In addition to these factors, genetic predispositions to obesity and inflammation in the Japanese population were shown to contribute much to the development of NASH. |
| Databáze: | OpenAIRE |
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