Plasmodium falciparum chloroquine resistance transporter is a H+-coupled polyspecific nutrient and drug exporter
| Autor: | Nathan Nelson, Hiroshi Omote, Sawako Moriyama, Mamiyo Kawakami, Tomoya Fukui, Yoshinori Moriyama, Narinobu Juge, Takaaki Miyaji, Haruka Iwai |
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| Rok vydání: | 2015 |
| Předmět: |
Drug Resistance
Protozoan Proteins Drug resistance Vacuole Pharmacology Chloroquine parasitic diseases medicine Amino Acids Electrochemical gradient chemistry.chemical_classification Multidisciplinary biology Membrane transport protein Membrane Transport Proteins Tetraethylammonium Plasmodium falciparum Transporter Biological Transport Biological Sciences biology.organism_classification Amino acid Biochemistry chemistry Verapamil biology.protein Protons medicine.drug |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 112(11) |
| ISSN: | 1091-6490 |
| Popis: | Significance Malaria caused by Plasmodium falciparum is a severe infectious disease with high mortality and morbidity rates worldwide. Chloroquine (CQ) is a widely used antimalarial agent, but the emergence and spread of CQ-resistant parasites is a growing global health problem. Although its physiological relevance remains unknown, P. falciparum CQ resistance transporter (PfCRT) confers CQ resistance through CQ egress from digestive vacuoles of P. falciparum . To address this issue, recombinant CQ-sensitive or CQ-resistant PfCRT proteins were purified and their transport activities were assessed. Both CQ-sensitive and CQ-resistant PfCRTs transported CQ, various antimalarial agents, and basic amino acids, indicating that PfCRT is a polyspecific drug and nutrient exporter. |
| Databáze: | OpenAIRE |
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