IMMU-14. REVEALING THE MANY MYELOID STATES IN HUMAN BRAIN TUMORS AND WAYS TO PERTURB THEM
| Autor: | L. Nicolas Gonzalez Castro, Kevin Petrecca, Zeyu Chen, Joshua D'Antonio, Bradley E. Bernstein, Tyler E. Miller, Julia A. Verga, Charles Couturier, Mario Suva, Chadi El Farran |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Tumor microenvironment Myeloid business.industry medicine.medical_treatment Cancer Human brain Immunotherapy 26th Annual Meeting & Education Day of the Society for Neuro-Oncology medicine.disease medicine.anatomical_structure Oncology Myeloid cells Cancer research medicine Organoid Low-Grade Glioma Neurology (clinical) business |
| Zdroj: | Neuro Oncol |
| Popis: | Recent breakthroughs in immunotherapy have revolutionized treatment for many types of cancer, but unfortunately trials of these therapies have failed to provide meaningful life-prolonging benefit for brain tumor patients, potentially due to abundant immunosuppressive myeloid cells in the tumor. Our ultimate goal is to reprogram immunosuppressive tumor associated myeloid cells to an antitumor state to enable effective immunotherapy. Towards this goal, we have deeply characterized the immune microenvironment of more than 50 primary high and low grade gliomas using high-throughput single-cell RNA-sequencing to reveal recurrent myeloid cell states and immunosuppressive programs across IDH1 wild-type and mutant tumors. We have also established a brain tumor organoid model from primary patient tissue that maintains all of the tumor microenvironment, including myeloid and other immune cells. We utilize the this model to functionally test data-driven reprogramming strategies and understand how they impact the states of tumor and immune cells in the ex vivo human tumor microenvironment. |
| Databáze: | OpenAIRE |
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