Redistribution of subcellular calcium in rat liver on administration of vanadate
| Autor: | T. Ramasarma, Vidya Shivaswamy, C. K. Ramakrishna Kurup, Sharada Gullapalli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Phenoxybenzamine Sodium Clinical Biochemistry chemistry.chemical_element Mitochondria Liver Pyruvate Dehydrogenase Complex Mitochondrion Calcium Biochemistry In vivo Internal medicine medicine Animals Vanadate Receptor Molecular Biology Adrenergic alpha-Antagonists Chemistry Respiration Rats Inbred Strains Cell Biology General Medicine Rats Perfusion Cytosol Endocrinology Vanadates Subcellular Fractions medicine.drug |
| Zdroj: | IndraStra Global. |
| ISSN: | 2381-3652 |
| Popis: | Mitochondria isolated from the livers of rats administered with sodium meta-, ortho-, or polyvanadate, but not vanadyl sulphate, exhibited enhanced Ca2+ -stimulated respiration and uptake of calcium. These effects were shown also by mitochondria isolated from livers perfused with polyvanadate. The concentration of acid-soluble calcium decreased significantly in the mitochondrial fraction on vanadate treatment, while that in the cytosol showed a corresponding increase. Phenoxybenzamine, an antagonist to alpha-adrenergic receptors, effectively inhibited vanadate-induced Ca2+ mobilization, but surgical sympathectomy was without effect. This is the first demonstration of vanadate mimicking alpha-adrenergic agonists in vivo. |
| Databáze: | OpenAIRE |
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