Comorbidity and Therapeutic Approaches in Patients with Necrobiosis Lipoidica
| Autor: | Finja Reinboldt-Jockenhöfer, Veronika Heusinger, Cornelia Erfurt-Berge, Joachim Dissemond, Regina Renner |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Calcineurin Inhibitors Medizin Comorbidity Dermatology Dapsone Necrobiosis lipoidica Young Adult Fumarates Diabetes mellitus Epidemiology Diabetes Mellitus medicine Cluster Analysis Humans Retrospective Studies Necrobiosis Lipoidica business.industry medicine.disease Thyroid Diseases Calcineurin Clinical research Concomitant Female Steroids business medicine.drug |
| Zdroj: | Dermatology. 238:148-155 |
| ISSN: | 1421-9832 1018-8665 |
| DOI: | 10.1159/000514687 |
| Popis: | Background: Necrobiosis lipoidica (NL) is a rare granulomatous disorder of unknown aetiology. Randomized controlled studies are not available due to it being an orphan disease. Objectives: We evaluated patients in 2 dermatological centres to cluster data about epidemiology, the therapeutic approaches for NL, and their efficacy. Materials and Methods: Comorbidity and the efficacy of the applied treatment was assessed for 98 patients. Results: We identified 54% of patients with concomitant diabetes and 19% with thyroidal disorders. Topical steroids (85.7%) were predominantly used followed by calcineurin inhibitors (31%) and phototherapy (41.8%). Systemically, fumaric acid esters were more frequently applied (26.8%) than steroids (24.4%) and dapsone (24.4%). Steroids, compression therapy, calcineurin inhibitors, phototherapy, fumaric acid esters, and dapsone showed remarkable efficacy. Conclusion: Therapeutic options were chosen individually in accordance with the severity of NL and presence of ulceration. Topical calcineurin inhibitors, systemic application of fumaric acid esters, and dapsone represent effective alternatives to the use of steroids. |
| Databáze: | OpenAIRE |
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