Metastatic carcinoma in the cervical lymph nodes from an occult primary: a conservative approach to the role of radiotherapy
| Autor: | Anil K. Anand, Roger J. Berry, Rob Glynne-Jones, Teresa E. Young |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Metastatic carcinoma Metastasis medicine Humans Radiology Nuclear Medicine and imaging Child Lymph node Aged Aged 80 and over Radiation business.industry Carcinoma Retrospective cohort study Neck dissection Middle Aged medicine.disease Primary tumor Surgery Radiation therapy Survival Rate medicine.anatomical_structure Oncology Cervical lymph nodes Head and Neck Neoplasms Lymphatic Metastasis Carcinoma Squamous Cell Neoplasms Unknown Primary Female business |
| Zdroj: | International journal of radiation oncology, biology, physics. 18(2) |
| ISSN: | 0360-3016 |
| Popis: | This retrospective study examines the results of treatment for cervical lymph node metastases from an unknown primary epithelial cancer of squamous cell or anaplastic histology. The analysis covers a series of 87 consecutive unselected patients at the Middlesex Hospital, London, in the years between 1954 and 1986. Fifty-eight patients received radiation therapy with a view to cure, 25 patients were treated with radiotherapy to a palliative dose, 1 patient only had a radical neck dissection, and 3 patients received no treatment apart from excision biopsy. In contrast to common practice in the United States, only a single patient received prophylactic radiation to the nasopharynx as part of the initial therapy. Overall actuarial survival for all patients (87) at 2 years was 43% and at 5 years 33%, and in the radically treated group (58) it was 52% and 40% respectively. Only 6 of the 87 patients (7%) subsequently revealed a primary tumor above the clavicles. Overall disease control above the clavicles was achieved in 53% (46/87), but was 64% (37/58) in the radically treated group. Guidelines for radiation therapy are discussed in view of these results. |
| Databáze: | OpenAIRE |
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