Epithelial membrane protein 2 is a prognostic indictor for patients with urothelial carcinoma of the upper urinary tract
| Autor: | Wen-Jeng Wu, Yow-Ling Shiue, Chih Jen Cheng, Hong Lin Cheng, Nan Haw Chow, Yi Wen Wang, Hsiao Sheng Liu, Shu Jem Su, Wei-Ming Li, Chee Yin Chai, Yin Sun, Tsuey Yu Chang |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Integrins Urologic Neoplasms Carcinogenesis Urinary system Integrin medicine.disease_cause Pathology and Forensic Medicine Mice Young Adult Cell Movement Cell Line Tumor Cell Adhesion Medicine Animals Humans Urothelium Cell adhesion Upper urinary tract Aged Cell Proliferation Proportional Hazards Models Aged 80 and over Severe combined immunodeficiency Membrane Glycoproteins biology business.industry Epithelial Cells Middle Aged medicine.disease Prognosis Isoflavones Gene Expression Regulation Neoplastic Membrane glycoproteins Protein Transport HEK293 Cells biology.protein Female business |
| Zdroj: | The American journal of pathology. 183(3) |
| ISSN: | 1525-2191 |
| Popis: | Upper urinary tract urothelial carcinoma is a relatively uncommon disease and is diagnosed more frequently at advanced stages. The prognosis of these patients mainly has been related to tumor stage and grade. As a result, the definition of prognostic indicators enabling precise patient selection is mandatory for neoadjuvant or adjuvant therapies. The epithelial membrane protein (EMP2) was identified as one of the up-regulated genes by isoflavones. EMP2 overexpression suppressed foci formation, anchorage-independent growth in vitro, and tumorigenicity in severe combined immunodeficiency mice (all P < 0.05). In addition, a cross-talk between EMP2 and integrins αV and β3 was shown in the regulation of cell adhesion and migration. Higher EMP2 expression was associated with a better progression-free survival (P = 0.008) and cancer-related death (P < 0.001). EMP2 was identified as a tumor-suppressor gene in urinary tract urothelial carcinoma and may be an innovative co-targeting candidate for designing integrin-based cancer therapy. |
| Databáze: | OpenAIRE |
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