Use of Antibiotics and Probiotics Reduces the Risk of Metachronous Gastric Cancer after Endoscopic Resection
Autor: | Kazuhiko Koike, Tetsuya Sumiyoshi, Yoku Hayakawa, Naohiro Yoshida, Tetsuro Honda, Yosuke Tsuji, Junya Arai, Takashi Ikeya, Takuya Kawahara, Nobumi Suzuki, Ryota Niikura, Atsuo Yamada, Masahiro Arai, Tsutomu Nishida, Shu Kiyotoki, Takashi Kawai, Kenkei Hasatani |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
QH301-705.5 medicine.drug_class Antibiotics gut microbiome Biology Gastroenterology General Biochemistry Genetics and Molecular Biology Article antibiotics 03 medical and health sciences 0302 clinical medicine endoscopic resection Internal medicine medicine Endoscopic resection Biology (General) metachronous gastric cancer General Immunology and Microbiology Incidence (epidemiology) Hazard ratio digestive oral and skin physiology Cancer Retrospective cohort study Helicobacter pylori biology.organism_classification medicine.disease Confidence interval probiotics 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology General Agricultural and Biological Sciences |
Zdroj: | Biology Volume 10 Issue 6 Biology, Vol 10, Iss 455, p 455 (2021) |
ISSN: | 2079-7737 |
DOI: | 10.3390/biology10060455 |
Popis: | Simple Summary Helicobacter pylori is the most important cause of gastric cancer, and its eradication reduces the incidence of gastric cancer after endoscopic resection. However, incidence of metachronous gastric cancer is still high. More studies are needed to identify other chemopreventive drugs that may reduce the incidence of this disease. In this study, we focused on the alteration of the intragastric microbiome and examined the association between the use of antibiotics and probiotic drugs and risk of metachronous gastric cancer. Our findings suggest that the gut microbiome is associated with metachronous gastric cancer development. Abstract Metachronous gastric cancer often occurs after endoscopic resection. Appropriate management, including chemoprevention, is required after the procedure. This study was performed to evaluate the association between medication use and the incidence of metachronous gastric cancer after endoscopic resection. This multicenter retrospective cohort study was conducted with data from nine hospital databases on patients who underwent endoscopic resection for gastric cancer between 2014 and 2019. The primary outcome was the incidence of metachronous gastric cancer. We evaluated the associations of metachronous gastric cancer occurrence with medication use and clinical factors. Hazard ratios were adjusted by age and Charlson comorbidity index scores, with and without consideration of sex, smoking status, and receipt of Helicobacter pylori eradication therapy during the study period. During a mean follow-up period of 2.55 years, 10.39% (140/1347) of all patients developed metachronous gastric cancer. The use of antibiotics other than those used for H. pylori eradication was associated with a lower incidence of metachronous gastric cancer than was non-use (adjusted hazard ratio (aHR) 0.56, 95% confidence interval (CI) 0.38–0.85, p = 0.006). Probiotic drug use was also associated with a lower incidence of metachronous gastric cancer compared with non-use (aHR 0.29, 95% CI 0.091–0.91, p = 0.034). In conclusion, the use of antibiotics and probiotic drugs was associated with a decreased risk of metachronous gastric cancer. These findings suggest that the gut microbiome is associated with metachronous gastric cancer development. |
Databáze: | OpenAIRE |
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