In vivo antileishmanial activity of Annona mucosa extracts
| Autor: | Ivan Bezerra Allaman, Izaltina Silva-Jardim, Janaína Paolucci Sales de Lima, Maria Lúcia B. Pinheiro |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) Short Communication medicine.medical_treatment RC955-962 030106 microbiology 030231 tropical medicine Antiprotozoal Agents Leishmaniasis Cutaneous Annona Mice 03 medical and health sciences 0302 clinical medicine In vivo Arctic medicine. Tropical medicine medicine Animals Chemotherapy Parasite hosting Leishmaniasis Leishmania Mice Inbred BALB C Leishmania amazonensis biology Traditional medicine Plant Extracts biology.organism_classification medicine.disease Disease Models Animal Infectious Diseases Leishmania amazonenses Parasitology |
| Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical, Vol 53 (2020) Revista da Sociedade Brasileira de Medicina Tropical |
| ISSN: | 1678-9849 0037-8682 |
| Popis: | INTRODUCTION: Leishmaniasis, a disease caused by a parasite endemic to large areas of tropical and subtropical countries, is a growing public health problem. METHODS: Male BALB/c mice were infected with Leishmania amazonensis and treated with extracts isolated from Annona mucosa. RESULTS: Treated groups had significantly reduced footpad swelling. The group treated intraperitoneally with hexane extract showed footpad swelling similar to groups treated with Pentamidine® and Glucantime®. Groups treated with dichloromethane extract and hexane extract presented the recovering phenotype associated with reduced parasite levels. CONCLUSIONS: Extracts of A. mucosa are promising sources of novel antileishmanial compounds. |
| Databáze: | OpenAIRE |
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