Inflammatory infiltration of metaplastic epithelium and correlation to previous diagnosis of esophagitis and Barrett's length
| Autor: | Irene Zouboulis-Vafiadis, Giorgos Bamias, Vasiliki Kalampoki, Vasilios Tzias, George Karamanolis, Evanthia Zampeli, Spiros D. Ladas, Sotiria Savva, Elias Xirouchakis, George Morfopoulos, Spyros Michopoulos, Dimitrios Kamberoglou |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Inflammation Long segment Gastroenterology Barrett Esophagus Esophagus Internal medicine medicine Humans Inflammatory infiltration Esophagitis Peptic Aged Retrospective Studies Aged 80 and over Metaplasia Chi-Square Distribution business.industry Mean age Middle Aged medicine.disease digestive system diseases Epithelium medicine.anatomical_structure Hernia Hiatal Barrett's esophagus Female medicine.symptom business Esophagitis |
| Zdroj: | Scandinavian journal of gastroenterology. 47(8-9) |
| ISSN: | 1502-7708 |
| Popis: | The contact of the gastric refluxate with the lower esophagus results in an inflammatory-mediated tissue damage. The role of inflammation both in the development and in the advance of Barrett's esophagus (BE) has not been elucidated. The aim of this study was to assess the inflammatory infiltration in metaplastic Barrett's epithelium and to explore the association of microscopic inflammation to healed esophagitis and Barrett's length.Inflammatory infiltration was qualitatively evaluated in well-characterized Barrett's specimens. Esophagitis was healed prior to histological sampling. Univariate comparative analysis was performed based on BE length.Ninety-eight patients (78 male, mean age 58.3 ± 13.3 yrs) were retrospectively studied. Thirty-three cases with long segment BE (LSBE) (33.7%) were spotted. Inflammatory infiltration was mild, moderate, and severe in 35 (35.7%), 54 (55.1%), and 9 (9.1%) specimens, respectively. The samples with moderate/severe inflammatory infiltration were obtained from patients who had more frequently been diagnosed with esophagitis (p = 0.025). Hiatal hernia (p = 0.001), esophagitis (p = 0.019), and previous use of anti-secretory drugs (p = 0.005) were more common in LSBE.Inflammatory infiltration of Barrett's epithelium was largely moderate despite preceding healing of erosions with PPIs. Previous diagnosis of esophagitis correlated to the degree of inflammation. No association of inflammation to Barrett's length was established. |
| Databáze: | OpenAIRE |
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