Utility of cardiac magnetic resonance imaging, echocardiography and electrocardiography for the prediction of clinical response and long-term survival following cardiac resynchronisation therapy

Autor: Michelle J. Butler, Maros Elsik, Andris H. Ellims, Andrew J. Taylor, Heinz Pfluger, James L. Hare
Rok vydání: 2013
Předmět:
Male
Time Factors
genetic structures
Cardiomyopathy
Kaplan-Meier Estimate
Ventricular Function
Left
Cardiac Resynchronization Therapy
Electrocardiography
Risk Factors
Natriuretic Peptide
Brain
Prospective Studies
Cardiac imaging
medicine.diagnostic_test
Ventricular Remodeling
Middle Aged
Echocardiography
Doppler
Treatment Outcome
cardiovascular system
Cardiology
Disease Progression
Female
Radiology
Cardiology and Cardiovascular Medicine
circulatory and respiratory physiology
Adult
medicine.medical_specialty
Magnetic Resonance Imaging
Cine
Disease-Free Survival
QRS complex
Cardiac magnetic resonance imaging
Predictive Value of Tests
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
cardiovascular diseases
Aged
Echocardiography
Doppler
Pulsed
Heart Failure
Bundle branch block
business.industry
Magnetic resonance imaging
Recovery of Function
medicine.disease
Peptide Fragments
Echocardiography
Doppler
Color
Cardiac Imaging Techniques
Heart Transplantation
business
Biomarkers
Zdroj: The international journal of cardiovascular imaging. 29(6)
ISSN: 1875-8312
Popis: Cardiac resynchronisation therapy (CRT) can reduce symptoms, hospitalisations, and mortality in patients with severe left ventricular (LV) systolic dysfunction and electro-mechanical dyssynchrony. Unfortunately, approximately 30 % of eligible patients fail to respond to CRT. This study prospectively compared electrocardiography (ECG), echocardiography, and cardiac magnetic resonance (CMR) imaging for the prediction of response to CRT. We performed ECG, echocardiography and CMR on 46 patients prior to planned CRT implantation. Patients were divided into predicted responder and non-responder groups using previously described criteria for each modality. Changes in indicators of CRT response were recorded 6 months post-implantation, and later for transplant-free survival. Less dyspnoea, lower levels of N-terminal pro-brain natriuretic peptide, more LV reverse remodelling, and longer transplant-free survival were observed in predicted responders compared to predicted non-responders using each of the three modalities (p < 0.05 for each comparison). Additionally, for patients with QRS duration
Databáze: OpenAIRE
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