Neural representation of newly instructed rule identities during early implementation trials
| Autor: | Holger Mohr, Theo A. J. Schäfer, Katharina Zwosta, Uta Wolfensteller, Hannes Ruge |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Ventrolateral prefrontal cortex Computer science QH301-705.5 Science rule representation Prefrontal Cortex Representation (arts) 050105 experimental psychology General Biochemistry Genetics and Molecular Biology Memorization 03 medical and health sciences task representation 0302 clinical medicine MVPA Parietal Lobe medicine Image Processing Computer-Assisted Humans 0501 psychology and cognitive sciences cognitive control Biology (General) Prefrontal cortex Implementation Brain Mapping Clinical Trials as Topic General Immunology and Microbiology General Neuroscience instruction-based learning 05 social sciences Flexibility (personality) General Medicine Magnetic Resonance Imaging rapid instructed task learning medicine.anatomical_structure Medicine Female 030217 neurology & neurosurgery Psychomotor Performance Coding (social sciences) Cognitive psychology Research Article Neuroscience Human |
| Zdroj: | eLife eLife, Vol 8 (2019) |
| ISSN: | 2050-084X |
| Popis: | By following explicit instructions, humans instantaneously get the hang of tasks they have never performed before. We used a specially calibrated multivariate analysis technique to uncover the elusive representational states during the first few implementations of arbitrary rules such as ‘for coffee, press red button’ following their first-time instruction. Distributed activity patterns within the ventrolateral prefrontal cortex (VLPFC) indicated the presence of neural representations specific of individual stimulus-response (S-R) rule identities, preferentially for conditions requiring the memorization of instructed S-R rules for correct performance. Identity-specific representations were detectable starting from the first implementation trial and continued to be present across early implementation trials. The increasingly fluent application of novel rule representations was channelled through increasing cooperation between VLPFC and anterior striatum. These findings inform representational theories on how the prefrontal cortex supports behavioral flexibility specifically by enabling the ad-hoc coding of newly instructed individual rule identities during their first-time implementation. |
| Databáze: | OpenAIRE |
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