Role of phosphatases in the biosynthesis of chlortetracycline inStreptomyces aureofaciens
| Autor: | V. Jechová, E. Čurdová, Z. Hošťálek |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
chemistry.chemical_classification
Chlortetracycline Inorganic pyrophosphatase Membranes ATP-diphosphohydrolase activity Apyrase Phosphatase General Medicine Biology Phosphate Microbiology Phosphoric Monoester Hydrolases Streptomyces Culture Media Phosphates chemistry.chemical_compound Enzyme Biochemistry chemistry Biosynthesis medicine Pyrophosphatases Mycelium medicine.drug |
| Zdroj: | Folia Microbiologica. 27:153-158 |
| ISSN: | 1874-9356 0015-5632 |
| DOI: | 10.1007/bf02877393 |
| Popis: | ATP diphosphohydrolase activity and inorganic pyrophosphatase reached two maxima during cultivation of the low- and high-producing variant of Streptomyces aureofaciens under conditions of phosphate limitation, i.e. after 30 and 70 h of cultivation. Increased levels of inorganic phosphate in a medium inhibitory to biosynthesis of chlortetracycline markedly decreased the levels of both enzymes. The ATP diphosphohydrolase activity was detected both in the supernatant and membrane fractions of the cell-free preparation of the mycelium. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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