Genetic Characterization of Salmonella Infantis with Multiple Drug Resistance Profiles Isolated from a Poultry-Farm in Chile
| Autor: | Juan Castro-Severyn, Claudia P. Saavedra, Mario Tello, Gabriel I. Krüger, Luis Alvarez-Thon, Eduardo Castro-Nallar, Laurence Molina, Diego E. Lorca, Coral Pardo-Esté, Alejandro A. Hidalgo, Yoelvis Sulbaran-Bracho, Phillippi Zepeda, Franck Molina, Francisco Remonsellez |
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| Přispěvatelé: | Sys2Diag-Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic (Sys2Diag), Centre National de la Recherche Scientifique (CNRS)-Alcediag |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Serotype Veterinary medicine Salmonella QH301-705.5 Salmonella Infantis Virulence Biology medicine.disease_cause Microbiology genomic 03 medical and health sciences Antibiotic resistance Virology Genetic variation medicine Biology (General) Pathogen stress resistance 030304 developmental biology [SDV.GEN]Life Sciences [q-bio]/Genetics 0303 health sciences 030306 microbiology poultry Strain (biology) 3. Good health virulence Multiple drug resistance |
| Zdroj: | Microorganisms Microorganisms, MDPI, 2021, ⟨10.3390/microorganisms9112370⟩ Microorganisms, Vol 9, Iss 2370, p 2370 (2021) Volume 9 Issue 11 |
| ISSN: | 2076-2607 |
| DOI: | 10.3390/microorganisms9112370 |
| Popis: | Salmonella comprises over 2500 serotypes and foodborne contamination associated with this pathogen remains an important health concern worldwide. During the last decade, a shift in serotype prevalence has occurred as traditionally less prevalent serotypes are increasing in frequency of infections, especially those related to poultry meat contamination. S. Infantis is one of the major emerging serotypes, and these strains commonly display antimicrobial resistance and can persist despite cleaning protocols. Thus, this work aimed to isolate S. Infantis strains from a poultry meat farm in Santiago, Chile and to characterize genetic variations present in them. We determined their genomic and phenotypic profiles at different points along the production line. The results indicate that the strains encompass 853 polymorphic sites (core-SNPs) with isolates differing from one another by 0–347 core SNPs, suggesting variation among them however, we found discrete correlations with the source of the sample in the production line. Furthermore, the pan-genome was composed of 4854 total gene clusters of which 2618 (53.9%) corresponds to the core-genome and only 181 (3.7%) are unique genes (those present in one particular strain). This preliminary analysis will enrich the surveillance of Salmonella, yet further studies are required to assess their evolution and phylogeny. |
| Databáze: | OpenAIRE |
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