Blood pressure changes after renal denervation are more pronounced in women and nondiabetic patients
| Autor: | Christoph Krismer, Markus Suppan, Robert Zweiker, Katharina Hohenstein-Scheibenecker, Cornelia Dechant, Ella Niederl, Bruno Watschinger, Andreas Zirlik, Johann Auer, Stefan P Glaser, Julia Kerschbaum, Thomas Sturmberger, Thomas W. Weiss, Thomas Weber, Miklos Rohla, Petra Maister, David Zweiker, Roman Reindl-Schwaighofer, Clemens Steinwender, Helmut Brussee, Thomas Lambert, Christian Koppelstaetter, Peter Gruener, Josef Sykora, Claudia Kindslehner |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Physiology Treatment outcome Patient subgroups MEDLINE Blood Pressure 030204 cardiovascular system & hematology Kidney 03 medical and health sciences Renal Artery 0302 clinical medicine Internal medicine Internal Medicine medicine Humans Registries 030212 general & internal medicine Aged Denervation business.industry Blood Pressure Determination Middle Aged Treatment Outcome medicine.anatomical_structure Blood pressure Multicenter study Austria Hypertension Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Hypertension. 37:2290-2297 |
| ISSN: | 0263-6352 |
| Popis: | Three recently published sham-controlled studies proved the efficacy of renal denervation (RDN) in hypertensive patients. The study presented here analyzed a nationwide multicentre registry database to clarify which patient subgroups benefit most from radiofrequency RDN.This is a post hoc analysis from the multicentre Austrian Transcatheter Renal Denervation Registry hosted by the Austrian Society of Hypertension. We correlated change of SBP after RDN to sex and presence/absence of comorbidities. Univariable correlation and multiple linear regression analyses were performed.Two hundred and ninety-one patients (43% women, median age 64 years) undergoing RDN between April 2011 and September 2014 were included in this analysis. Mean baseline ambulatory 24 h BP (systolic/diastolic) was 150 ± 18/89 ± 14 mmHg and mean baseline office BP was 170 ± 16/94 ± 14 mmHg.After RDN, mean ambulatory 24 h BP reduction was 9 ± 19/6 ± 16 mmHg. The following features were associated with a good response to RDN: high baseline systolic ambulatory BP, high baseline diastolic office BP, female sex, absence of diabetes mellitus, and absence of peripheral artery disease. Multivariable analysis identified female sex and absence of diabetes mellitus as strongest predictors for ambulatory BP reduction, although those groups had the lowest baseline ambulatory BP.Ambulatory BP reductions after RDN were substantially more pronounced in female and in nondiabetic patients despite lower baseline BP. It is concluded that in terms of efficacy female patients and nondiabetic patients might benefit more from RDN. |
| Databáze: | OpenAIRE |
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