Anti-Cyclic Citrullinated Peptide Antibody as a Predictor of Rheumathoid Arthritis Complications
| Autor: | Mevludin Mekic, Emina Hadzigrahic |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Arthritis Disease Peptides Cyclic Gastroenterology Arthritis Rheumatoid chemistry.chemical_compound Quality of life Rheumatoid Factor antibody Internal medicine medicine Citrulline Humans Rheumatoid factor skin and connective tissue diseases Autoantibodies Original Paper biology business.industry General Medicine Middle Aged Prognosis medicine.disease Titer arthritis chemistry Rheumatoid arthritis citrulline Disease Progression biology.protein Female Antibody business Biomarkers Follow-Up Studies |
| Zdroj: | Medical Archives |
| ISSN: | 0350-199X |
| Popis: | Introduction: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease, with more frequent occurrence in the female gender, it primarily affects the lining of the synovial joints, and is associated with lower quality of life, inability to work, progressive disability, and all of these patients are more likely to develop other comorbidities. Aim: To display the role of anti-cyclic citrullinated peptide antibody (anti-CCP) in evaluating RA complications during a one-year follow-up, and compare its values with values of rheumatoid factor (RF). Methods: The study included 40 patients with RA, out of which 6 were excluded during the 1-year follow-up. All patients were treated with anti-rheumatics, methothrexate 15-25mg, occasionally corticosteroids at the same doses. Results: Anti-CCP values were also significantly higher during the second examination and were 5.0 ± 1.9 (range 0.5-7.6) compared to the first examination when they were 4.2 ± 1.3 (range 0.4-6.2) indicating a higher sensitivity of Anti-CCP in detecting of disease progression (t = -2.064; p = 0.043). Anti-CCP values were statistically significant in patients with complications compared to those without during the first examination and at follow-up after one year (t = 5,382; p = 0.0001). Conclusion: The positivity of anti-CCP antibodies is a useful marker in terms of predicting the course and prognosis of the RA. A higher titer of anti-CCP antibodies represents a poorer prognosis for the disease. Determination of the presence of anti-CCP antibodies should be performed as a routine examination in all patients with suspected rheumatoid arthritis. |
| Databáze: | OpenAIRE |
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