The systemic cytokine environment is permanently altered in multiple myeloma
| Autor: | Kyle D. Bemis, Julia Kirshner, Mary M. Zheng, John E. Shively, Zhifang Zhang, Andrew Belch, Linda M. Pilarski |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Chemokine Aging medicine.medical_treatment lcsh:Medicine Monoclonal Gammopathy of Undetermined Significance Plasma Cell Disorders Hematologic Cancers and Related Disorders 0302 clinical medicine Homeostasis lcsh:Science Multiple myeloma Aged 80 and over 0303 health sciences Sex Characteristics Multidisciplinary biology Remission Induction Discriminant Analysis Hematology Middle Aged 3. Good health Cytokine medicine.anatomical_structure Phenotype Oncology 030220 oncology & carcinogenesis Cytokines Medicine Female medicine.symptom Inflammation Mediators Multiple Myeloma Research Article Adult Clinical Research Design Immunology Inflammation 03 medical and health sciences Young Adult medicine Humans Myelomas and Lymphoproliferative Diseases Biology B cell 030304 developmental biology Aged business.industry lcsh:R Modeling Cancer Cancers and Neoplasms Complement System Proteins medicine.disease Immunity Humoral Immune System Case-Control Studies biology.protein lcsh:Q Bone marrow business Monoclonal gammopathy of undetermined significance |
| Zdroj: | PLoS ONE, Vol 8, Iss 3, p e58504 (2013) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Multiple myeloma (MM) is an incurable bone marrow malignancy of the B cell lineage. Utilizing multiplex Luminex technology we measured levels of 25 cytokines in the plasma of normal donors (n = 177), those with monoclonal gammopathy of undetermined significance (n = 8), and MM patients (n = 55) with either active disease, on treatment, or in remission. The cytokine levels were compared between normal donors and MM patients as well as between various phases of MM, and discriminant analysis was used to create a predictive classification model based on the differentially expressed cytokines. Evaluating age- and gender-dependence of cytokine expression, we determined that with age there is a shift toward a pro-inflammatory environment. Moreover, we observed a strong gender bias in cytokine expression. However, the profile of differentially expressed cytokines was heavily skewed toward an anti-inflammatory, pro-tumorigenic response in patients with MM. Significantly, our predictive model placed all patients in remission in the same category as those with active disease. Thus, our study demonstrates that the homeostasis of systemic cytokines is not restored when MM patients enter remission, suggesting that once an individual has cancer, the microenvironment is permanently altered and the system is primed for a relapse. |
| Databáze: | OpenAIRE |
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