Protein kinase C as a peripheral biomarker for Alzheimer's disease
| Autor: | Agnes Janoshazi, Jean de Barry, Corinne Liegeois |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Aging
Parkinson's disease Erythrocytes Tau protein Hyperphosphorylation Biology Biochemistry Endocrinology Alzheimer Disease Genetics medicine Humans Molecular Biology Protein kinase C Protein Kinase C Aged chemistry.chemical_classification Cell Biology medicine.disease Red blood cell Enzyme medicine.anatomical_structure chemistry Cancer research biology.protein Biomarker (medicine) Alzheimer's disease Biomarkers |
| Zdroj: | Experimental gerontology. 45(1) |
| ISSN: | 1873-6815 |
| Popis: | Numerous studies have been performed, which assess an important role of protein kinase C (PKC) in the physiopathology of Alzheimer disease (AD). The alteration of PKC activity stimulates amyloid-beta peptides production and protein tau hyperphosphorylation. This recently led to consider PKC as a potential therapeutic target for disease modifying drugs. Moreover PKC alterations were also observed in peripheral cells including blood cells. This short review recalls the main findings on the role of PKC in the disease process and focuses on its use as an AD biomarker in blood cells. Using fluorescent probes specific for PKC, it is possible to detect the conformational changes of the enzyme in living cells. Such probes can be used to detect PKC alterations in red blood cells and thus to distinguish AD patients from healthy controls with unmatched specificity and sensitivity. |
| Databáze: | OpenAIRE |
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