Normal Anatomy, Histology, and Spontaneous Pathology of the Kidney, and Selected Renal Biomarker Reference Ranges in the Cynomolgus Monkey
| Autor: | Calvert Louden, Chidozie Amuzie, Alys Bradley, Kevin McDorman, Vinicius Carreira, Jing Ying Ma, Ronnie Chamanza, Brad Blankenship, Stuart W. Naylor |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Pathology medicine.medical_specialty Interstitial nephritis Urinalysis Kidney Kidney Function Tests Toxicology Macaque Pathology and Forensic Medicine Species Specificity Glomerulopathy biology.animal Metaplasia medicine Animals Molecular Biology Pathological biology urogenital system Histology Organ Size Cell Biology medicine.disease Immunohistochemistry Major duodenal papilla Macaca fascicularis medicine.anatomical_structure Female Kidney Diseases medicine.symptom Biomarkers |
| Zdroj: | Toxicologic Pathology. 47:612-633 |
| ISSN: | 1533-1601 0192-6233 |
| Popis: | To further our understanding of the nonhuman primate kidney anatomy, histology, and incidences of spontaneous pathology, we retrospectively examined kidneys from a total of 505 control Cynomolgus monkeys ( Macaca fascicularis; 264 male and 241 females) aged 2 to 6 years, from toxicity studies. Kidney weights, urinalysis, and kidney-related clinical biochemistry parameters were also evaluated. Although the functional anatomy of the monkey kidney is relatively similar to that of other laboratory animals and humans, a few differences and species-specific peculiarities exist. Unlike humans, the macaque kidney is unipapillate, with a relatively underdeveloped papilla, scarce long loops of Henle, and a near-equivalent cortical to medullary ratio. The most common spontaneous microscopic findings were interstitial infiltrates or interstitial nephritis and other tubular lesions, but several forms of glomerulopathy that may be interpreted as drug-induced were occasionally observed. Common incidental findings of little pathological significance included: papillary mineralization, epithelial pigment, multinucleate cells, cuboidal metaplasia of the Bowman’s capsule, and urothelial inclusions. Kidney weights, and some clinical chemistry parameters, showed age- and sex-related variations. Taken together, these data will aid the toxicologic pathologist to better evaluate the nonhuman primate kidney and assess the species’ suitability as a model for identifying and characterizing drug-induced injury. |
| Databáze: | OpenAIRE |
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